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https://ir.swu.ac.th/jspui/handle/123456789/14103| ชื่อเรื่อง: | Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs |
| ผู้แต่ง: | Sudta P. Jiarawapi P. Suksamrarn A. Hongmanee P. Suksamrarn S. |
| Keywords: | 3,6 di o (4 bromobutyl)tetrahydro alpha mangostin 3,6 di o allyltetrahydro alpha mangostin 3,6 di o benzyltetrahydro alpha mangostin 3,6 di o ethyl alpha mangostin 3,6 di o methyl alpha mangostin 6 methoxytetrahydro alpha mangostin 6 o (4 bromobutyl)tetrahydro alpha mangostin 6 o allyltetrahydro alpha mangostin 6 o benzyltetrahydro alpha mangostin 6 o butyltetrahydro alpha mangostin 6 o ethyl alpha mangostin 6 o methyl alpha mangostin 6 o methyltetrahydro alpha mangostin 6 o methyltetrahydro alpha mangostin 3 o acetate 6 o pentyltetrahydro alpha mangostin alpha mangostin 3,6 di o acetate alpha mangostin 3,6 di o benzoate alpha mangostin 6 o acetate alpha mangostin 6 o benzoate alpha mangostin derivative antimycobacterial agent tetrahydro alpha mangostin tetrahydro alpha mangostin 3,6 di o acetate tetrahydro alpha mangostin 3,6 di o benzoate tetrahydro alpha mangostin 3,6 di o butyrate tetrahydro alpha mangostin 3,6 di o propionate tetrahydro alpha mangostin 6 o acetate tetrahydro alpha mangostin 6 o benzoate tuberculostatic agent unclassified drug unindexed drug acylation alkylation antibacterial activity article drug activity drug structure drug synthesis minimum inhibitory concentration multidrug resistance Mycobacterium tuberculosis nonhuman Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Microbial Sensitivity Tests Mycobacterium tuberculosis Xanthones |
| วันที่เผยแพร่: | 2013 |
| บทคัดย่อ: | A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14103 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873593744&doi=10.1248%2fcpb.c12-00874&partnerID=40&md5=7044536b1db8ec73e49d221fe3bc1dfb |
| ISSN: | 92363 |
| Appears in Collections: | Scopus 1983-2021 |
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