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dc.contributor.authorWongchitrat P.
dc.contributor.authorMukda S.
dc.contributor.authorPhansuwan-Pujito P.
dc.contributor.authorGovitrapong P.
dc.description.abstract•Chronic d-amphetamine altered the daily pattern of clock genes expressions in the rat striatum.•Bmal1 was shifted from a diurnal to a nocturnal pattern by d-amphetamine treatments.•d-Amphetamine altered the Rev-erbα rhythm expression in the striatum was shown for the first time. Drug addicts have severe disruptions in many physiological and behavioral rhythms, such as the sleep/wake cycle. Interestingly, amphetamine, a psychostimulant, is able to alter many circadian patterns, which are independent of the master biological clock located in the suprachiasmatic nucleus. To increase our understanding of the circadian regulation of amphetamine on clock gene expression, rats received subcutaneous injections of d-amphetamine and the clock gene mRNA levels were analyzed using real-time PCR to obtain a daily profile. In the striatum, acute injection of d-amphetamine did not alter Period (. Per). 1, Per2 and Reverse erythroblastosis virus α (. Rev-erbα) expressions. Chronic administration shifted the phase of Per1 and Per2 expressions from a nocturnal to diurnal pattern and advance shifted the peak of Rev-erbα in d-amphetamine-treated animals. In contrast, the rhythm of Brain and muscle Arnt-like protein-1 (. Bmal1) was shifted from a diurnal to a nocturnal pattern by both acute and chronic treatments. These results demonstrated that chronic d-amphetamine treatment altered the expression of clock genes in the striatum. This might further influence the expression of related gene within the striatum and lead to behavioral and physiological changes which are associated to drug addiction. © 2013 Elsevier Ireland Ltd.
dc.subjectmessenger RNA
dc.subjectprotein BMAL1
dc.subjecttranscription factor CLOCK
dc.subjectAlpha virus
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectchronic drug administration
dc.subjectcircadian rhythm
dc.subjectclock gene
dc.subjectcontrolled study
dc.subjectcorpus striatum
dc.subjectdrug dependence
dc.subjectgene expression
dc.subjectpriority journal
dc.subjectreal time polymerase chain reaction
dc.subjectreverse erythroblastosis virus alpha
dc.subjectsuprachiasmatic nucleus
dc.subjectvirus expression
dc.subjectARNTL Transcription Factors
dc.subjectCentral Nervous System Stimulants
dc.subjectCircadian Rhythm
dc.subjectCorpus Striatum
dc.subjectDose-Response Relationship, Drug
dc.subjectGene Expression
dc.subjectNuclear Receptor Subfamily 1, Group D, Member 1
dc.subjectPeriod Circadian Proteins
dc.subjectRats, Wistar
dc.titleEffect of amphetamine on the clock gene expression in rat striatum
dc.identifier.bibliograpycitationNeuroscience Letters. Vol 542, No. (2013), p.126-130
Appears in Collections:Scopus 1983-2021

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