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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14022
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dc.contributor.authorWangchuk P.
dc.contributor.authorPyne S.G.
dc.contributor.authorKeller P.A.
dc.contributor.authorITaweechotipatr M.
dc.contributor.authorKamchonwongpaisan S.
dc.date.accessioned2021-04-05T03:32:52Z-
dc.date.available2021-04-05T03:32:52Z-
dc.date.issued2014
dc.identifier.issn1934578X
dc.identifier.other2-s2.0-84905105669
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14022-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84905105669&doi=10.1177%2f1934578x1400900719&partnerID=40&md5=c221e6ea9a07d1da5207bbc4dc70610c
dc.description.abstractWith the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.
dc.subjectbergapten
dc.subjectcycloguanil
dc.subjectelemicin
dc.subjecteugenol
dc.subjectfolic acid antagonist
dc.subjectfurocoumarin derivative
dc.subjectisoapiol
dc.subjectisopimpinellin
dc.subjectmyristicin
dc.subjectoxypeucedanin
dc.subjectphenyl group
dc.subjectphenylpropanoid derivative
dc.subjectplant extract
dc.subjectPleurospermum amabile extract
dc.subjectpsoralen
dc.subjectpyrimethamine
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectantibacterial activity
dc.subjectantimalarial activity
dc.subjectarticle
dc.subjectBacillus subtilis
dc.subjectBhutan
dc.subjectcontrolled study
dc.subjectdrug isolation
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmedicinal plant
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectPlasmodium
dc.subjectPleurospermum amabile
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectAntifungal Agents
dc.subjectAntimalarials
dc.subjectApiaceae
dc.subjectBacteria
dc.subjectBhutan
dc.subjectCandida
dc.subjectCercopithecus aethiops
dc.subjectMolecular Structure
dc.subjectPlants, Medicinal
dc.subjectPlasmodium falciparum
dc.subjectPropanols
dc.subjectPsoralens
dc.subjectVero Cells
dc.titlePhenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationNatural Product Communications. Vol 9, No.7 (2014), p.957-960
dc.identifier.doi10.1177/1934578x1400900719
Appears in Collections:Scopus 1983-2021

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