Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13968
ชื่อเรื่อง: Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities
ผู้แต่ง: Pingaew R.
Worachartcheewan A.
Prachayasittikul V.
Prachayasittikul S.
Ruchirawat S.
Prachayasittikul V.
Keywords: 8 aminoquinoline derivative
copper complex
doxorubicin
etoposide
ligand
manganese derivative
metal complex
nickel complex
reactive nitrogen species
reactive oxygen metabolite
superoxide
superoxide dismutase
transition element
uracil derivative
antioxidant activity
article
cancer cell culture
complex formation
controlled study
drug cytotoxicity
drug synthesis
human
human cell
IC 50
infrared spectroscopy
priority journal
structure activity relation
X ray powder diffraction
วันที่เผยแพร่: 2013
บทคัดย่อ: Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13968
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887864374&doi=10.2174%2f15701808113109990004&partnerID=40&md5=a3eee064f49f651dd797425acaef207d
ISSN: 15701808
Appears in Collections:Scopus 1983-2021

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