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https://ir.swu.ac.th/jspui/handle/123456789/13968| Title: | Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities |
| Authors: | Pingaew R. Worachartcheewan A. Prachayasittikul V. Prachayasittikul S. Ruchirawat S. Prachayasittikul V. |
| Keywords: | 8 aminoquinoline derivative copper complex doxorubicin etoposide ligand manganese derivative metal complex nickel complex reactive nitrogen species reactive oxygen metabolite superoxide superoxide dismutase transition element uracil derivative antioxidant activity article cancer cell culture complex formation controlled study drug cytotoxicity drug synthesis human human cell IC 50 infrared spectroscopy priority journal structure activity relation X ray powder diffraction |
| Issue Date: | 2013 |
| Abstract: | Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13968 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887864374&doi=10.2174%2f15701808113109990004&partnerID=40&md5=a3eee064f49f651dd797425acaef207d |
| ISSN: | 15701808 |
| Appears in Collections: | Scopus 1983-2021 |
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