Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13874
ชื่อเรื่อง: Effects of curcumin on restoration and improvement of microvasculature characteristic in diabetic rat’s choroid of eye
ผู้แต่ง: Khimmaktong W.
Petpiboolthai H.
Sriya P.
Anupunpisit V.
Keywords: curcumin
glucose
streptozocin
curcumin
nonsteroid antiinflammatory agent
animal experiment
animal model
artery constriction
artery dilatation
Article
blood vessel diameter
blood vessel function
choroid vascularization
ciliary artery
controlled study
diabetes mellitus
male
microaneurysm
microvasculature
nonhuman
pathology
rat
scanning electron microscopy
supplementation
animal
capillary
choroid
Diabetes Mellitus, Experimental
Diabetic Neuropathies
drug effects
vascularization
Animals
Anti-Inflammatory Agents, Non-Steroidal
Capillaries
Choroid
Curcumin
Diabetes Mellitus, Experimental
Diabetic Neuropathies
Male
Microscopy, Electron, Scanning
Microvessels
Rats
วันที่เผยแพร่: 2014
บทคัดย่อ: Objective: To investigate the effect of curcumin on microvasculature changes in STZ-induced diabetic rat’s choroid of eye. Material and Method: Male rats were divided into three groups: control (C) Diabetic rats were induced by streptozotocin (STZ) (60 mg/kg BW) (DM) diabetic rats treated with curcumin (DMC) (200 mg/kg BW). After 8 weeks of experiments, microvasculature changes of rat’s choroid were studied under vascular corrosion cast technique with scanning electron microscope (SEM). Results: There were pathology and destruction of choroid microvasculature of DM group that revealed reduced and shrunken sizes of large and small blood vessels, compared with control group; long posterior ciliary arteries (LPCAs) (C = 113.70±1.38, DM = 83.53±2.70, DMC = 109.64±3.41 μm), choroid arteries (C = 94.97±2.79, DM = 59.36±2.61, DMC= 80.31±3.73 μm), vortex veins (C = 74.11±3.24, DM = 46.71±2.56, DMC = 64.66±3.60 μm), and Choriocapillaris (choroidal capillaries) (C = 13.61±0.62, DM = 4.46±0.24, DMC = 9.96±0.70 μm), respectively. In DM group, LPCAs and Choroid arteries were tortuous and showed shrinkage. Vortex veins became narrow. Choriocapillaris showed the pathological characteristics of vascular lesions including of shrinkage, constriction, microaneurysm and blind ending. Fascinatingly, Choroid microvasculature of the eye in curcumin treated group developed into regenerate and repaired conditions with healthy and normal characteristics. Conclusion: Efficiency of curcumin treatment beneficially repaired and regenerated the redevelopment of choroid’s microvascular complications of eye in 8-week experiments. Potential treatment with curcumin in diabetes has demonstrated in a meaningful way the therapeutic consequences in the improvement and recovery of choroidal blood vessels in eye pathology of diabetic rats. © 2014, Medical Association of Thailand. All Rights Reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13874
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929614008&partnerID=40&md5=aebdd22e440f9a009b72b928eb0fdd9c
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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