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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13796
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dc.contributor.authorNontakham J.
dc.contributor.authorCharoenram N.
dc.contributor.authorUpamai W.
dc.contributor.authorTaweechotipatr M.
dc.contributor.authorSuksamrarn S.
dc.date.accessioned2021-04-05T03:32:26Z-
dc.date.available2021-04-05T03:32:26Z-
dc.date.issued2014
dc.identifier.issn2536269
dc.identifier.other2-s2.0-84886913190
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13796-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84886913190&doi=10.1007%2fs12272-013-0266-4&partnerID=40&md5=6680d89608ae6dcaf2bfa5fb4daf7ed2
dc.description.abstractA new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (2-9 and 11), a biphenyl (10) and three biflavonoids (12-14) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 11-14 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin. © 2013 The Pharmaceutical Society of Korea.
dc.subjectantiinfective agent
dc.subjectxanthone derivative
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectGarcinia
dc.subjectHelicobacter pylori
dc.subjectisolation and purification
dc.subjectmass spectrometry
dc.subjectmicrobial sensitivity test
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectplant root
dc.subjectAnti-Bacterial Agents
dc.subjectGarcinia
dc.subjectHelicobacter pylori
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMass Spectrometry
dc.subjectMicrobial Sensitivity Tests
dc.subjectPlant Roots
dc.subjectXanthones
dc.titleAnti-Helicobacter pylori xanthones of Garcinia fusca
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationArchives of Pharmacal Research. Vol 37, No.8 (2014), p.972-977
dc.identifier.doi10.1007/s12272-013-0266-4
Appears in Collections:Scopus 1983-2021

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