Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13775
ชื่อเรื่อง: Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats
ผู้แต่ง: Jariyapongskul A.
Areebambud C.
Suksamrarn S.
Mekseepralard C.
Keywords: advanced glycation end product
advanced glycation end product receptor
alpha mangostin
antidiabetic agent
antiinflammatory agent
antioxidant
cholesterol
glucose
hemoglobin A1c
insulin
malonaldehyde
mangosteen extract
plant extract
triacylglycerol
tumor necrosis factor alpha
unclassified drug
vasculotropin
glucose blood level
glycosylated hemoglobin
mangostin
tumor necrosis factor
vasculotropin A
xanthone derivative
animal experiment
animal model
antidiabetic activity
antiglycation activity
antiinflammatory activity
antioxidant activity
Article
blood retina barrier
cholesterol blood level
controlled study
diabetic retinopathy
drug activity
drug effect
drug efficacy
eye blood flow
glucose blood level
hemoglobin blood level
homeostasis model assessment of insulin resistance
hyperglycemia
insulin blood level
male
mean arterial pressure
metabolic parameters
non insulin dependent diabetes mellitus
nonhuman
perfusion
rat
retina blood vessel
statistical analysis
triacylglycerol blood level
animal
blood
blood retina barrier
complication
diet therapy
drug effects
experimental diabetes mellitus
human
hyperglycemia
metabolism
non insulin dependent diabetes mellitus
pathology
pathophysiology
Animalia
Rattus
Animals
Blood Glucose
Blood-Retinal Barrier
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 2
Diabetic Retinopathy
Hemoglobin A, Glycosylated
Humans
Hyperglycemia
Male
Rats
Tumor Necrosis Factor-alpha
Vascular Endothelial Growth Factor A
Xanthones
วันที่เผยแพร่: 2015
บทคัดย่อ: The present study examined effects of alpha-mangostin (α-MG) supplementation on the retinal microvasculature, including ocular blood flow (OBF) and blood-retinal barrier (BRB) permeability in a type 2 diabetic animal model. Male Sprague-Dawley rats were divided into four groups: normal control and diabetes with or without α-MG supplementation. Alpha-mangostin (200 mg/Kg/day) was administered by gavage feeding for 8 weeks. The effects of α-MG on biochemical and physiological parameters including mean arterial pressure (MAP), OBF, and BRB leakage were investigated. Additionally, levels of retinal malondialdehyde (MDA), advance glycation end products (AGEs), receptor of advance glycation end products (RAGE), tumour necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were evaluated. The elevated blood glucose, HbA1c, cholesterol, triglyceride, serum insulin, and HOMA-IR were observed in DM2 rats. Moreover, DM2 rats had significantly decreased OBF but statistically increased MAP and leakage of the BRB. The α-MG-treated DM2 rats showed significantly lower levels of retinal MDA, AGEs, RAGE, TNF-α, and VEGF than the untreated group. Interestingly, α-MG supplementation significantly increased OBF while it decreased MAP and leakage of BRB. In conclusion, α-MG supplementation could restore OBF and improve the BRB integrity, indicating its properties closely associated with antihyperglycemic, antioxidant, anti-inflammatory, and antiglycation activities. © 2015 Amporn Jariyapongskul et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13775
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928561973&doi=10.1155%2f2015%2f785826&partnerID=40&md5=45a078d21e09e60eacef53941977067a
ISSN: 23146133
Appears in Collections:Scopus 1983-2021

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