Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13695
ชื่อเรื่อง: Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression
ผู้แต่ง: Wiranidchapong C.
Ruangpayungsak N.
Suwattanasuk P.
Shuwisitkul D.
Tanvichien S.
Keywords: ibuprofen
polymer
povidone
drug carrier
ibuprofen
plasticizer
povidone
tablet
Article
calorimeter
drug release
drug solubility
glass transition temperature
infrared spectroscopy
mathematical analysis
scanning electron microscope
scanning electron microscopy
storage temperature
tablet compression
tablet matrix
tablet surface
water absorption
chemistry
differential scanning calorimetry
drug formulation
drug release
drug storage
medicinal chemistry
pressure
procedures
tablet
temperature
transition temperature
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Drug Carriers
Drug Compounding
Drug Liberation
Drug Storage
Ibuprofen
Microscopy, Electron, Scanning
Plasticizers
Povidone
Pressure
Tablets
Temperature
Transition Temperature
วันที่เผยแพร่: 2015
บทคัดย่อ: The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45 °C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (Tg) of ibuprofen in KSR at 0-100% w/w based on the principle of Gordon-Taylor equation. At 45 °C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30 °C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the Tg of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon-Taylor equation. © 2014 Informa Healthcare USA, Inc.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13695
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930509716&doi=10.3109%2f03639045.2014.925917&partnerID=40&md5=1f6723b890038194cf59409662b7feb6
ISSN: 3639045
Appears in Collections:Scopus 1983-2021

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