Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13641
ชื่อเรื่อง: Apolipoprotein E receptor 2 gene polymorphisms associated with dyslipidemia among thai population
ผู้แต่ง: Thongket P.
Rattanathanawan K.
Seesom W.
Sukhumsirichart W.
Keywords: apolipoprotein E2
high density lipoprotein cholesterol
low density lipoprotein cholesterol
triacylglycerol
lipid
low density lipoprotein receptor related protein
low density lipoprotein receptor-related protein 8
adult
apolipoprotein e receptor 2 gene
Article
cholesterol blood level
controlled study
DNA extraction
DNA polymorphism
dyslipidemia
female
gene
high resolution melting analysis
human
lipid blood level
major clinical study
male
real time polymerase chain reaction
single nucleotide polymorphism
Thai (people)
allele
Asian continental ancestry group
blood
case control study
chi square distribution
dyslipidemia
genetics
genotype
middle aged
polymerase chain reaction
risk factor
Alleles
Asian Continental Ancestry Group
Case-Control Studies
Chi-Square Distribution
Dyslipidemias
Female
Genotype
Humans
LDL-Receptor Related Proteins
Lipids
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Risk Factors
วันที่เผยแพร่: 2015
บทคัดย่อ: Background: Dyslipidemia is an abnormal amount of lipids and/or lipoproteins in the blood. It is a major risk factor of coronary heart disease and atherosclerosis. Objective: This study investigated two single nucleotide polymorphisms (SNPs) in the apolipoprotein E receptor 2 (ApoER2) gene in association with risk of dyslipidemia in the Thai patients. Material and Method: Four hundred blood samples including dyslipidemia patient (200) and unrelated normal control (200) were included in this study. Serum lipids were examined. DNAs were extracted and genotyped by using polymerase chain reaction (PCR) followed by high-resolution melting (HRM) analysis. The differences in genotype distribution between patient and normal control were assessed by Chi-square test of the SPSS software version 11.5. Results: The data analysis revealed that two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia. The rs3737984 showed significant association at p-value = 0.001, in which A alleles informed the decreased risk of dyslipidemia [odds ratio and 95% CI of A allele, 0.42 (0.28-0.65)]. In contrast, the rs2297660 exhibited strongest association with an increase risk of dyslipidemia [p-value = 0.001, odds ratio and 95% CI for the A allele was 2.38 (1.49-3.80)]. Conclusion: The rs2297660 may be used as biomarker for the risk of dyslipidemia in Thai ethnic. © 2015, Medical Association of Thailand. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13641
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957696150&partnerID=40&md5=59df8c0aa2bdef32503b2bf56bb7dbd6
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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