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ชื่อเรื่อง: | ADIPOQ polymorphisms among Thais with pre-diabetes |
ผู้แต่ง: | Chaikhiandee S. Phonrat B. Tungtrongchitr A. Suriyaprom K. Chuengsamarn S. Uttamachai C. Tungtrongchitr R. |
Keywords: | adiponectin ADIPOQ protein, human adult case control study female genetic polymorphism genetic predisposition genetics genotype human impaired glucose tolerance male middle aged retrospective study Thailand Adiponectin Adult Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Polymorphism, Genetic Prediabetic State Retrospective Studies Thailand |
วันที่เผยแพร่: | 2016 |
บทคัดย่อ: | Studies have shown that polymorphisms of adiponectin gene (ADIPOQ) are associated with risk of developing type 2 diabetes mellitus (T2DM). However, no studies have investigated the association between genetic variants of ADIPOQ and pre-diabetes, a group at higher risk for developing T2DM. A total of 75 pre-diabetes and 130 normal subjects were recruited from volunteers in Bangkok, Thailand. Individuals with pre-diabetes were selected based on American Diabetes Association diagnostic criteria. Six ADIPOQ polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. ADIPOQ polymorphism rs266729 C>G is significantly associated with pre-diabetes (p = 0.006). CG/GG genotypes were found among 60% and 40% of pre-diabetes and normal subjects, respectively. SNP rs266729 C>G was associated with increased pre-diabetes risk (OR = 2.64; 95% CI: 1.18-5.89, p = 0.018). No significant differences were found between pre-diabetes and normal subjects for other ADIPOQ polymorphisms. However, haplotype analysis revealed that haplotype GGTAAT is significantly associated with pre-diabetes when compared with GCGAAC reference haplotype (OR = 22.31; 95% CI: 1.37-361.93, p = 0.03). Our data indicate that ADIPOQ rs266729 C>G polymorphism may contribute to the genetic risk of pre-diabetes and provide preliminary data useful in genetic screening for pre-diabetes among Thais. © 2017, SEAMEO TROPMED Network. All Rights Reserved. |
URI: | https://ir.swu.ac.th/jspui/handle/123456789/13582 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024488451&partnerID=40&md5=b42247ab1c2e7a563d78e8aeef732e46 |
ISSN: | 1251562 |
Appears in Collections: | Scopus 1983-2021 |
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