Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13573
ชื่อเรื่อง: Thermal, mechanical and drug release characteristics of an acrylic film using active pharmaceutical ingredient as non-traditional plasticizer
ผู้แต่ง: Wiranidchapong C.
Kieongarm W.
Managit C.
Phrompittayarat W.
Keywords: chlorpheniramine maleate
eudragit
polyacrylic acid
surfactant
eudragit
plasticizer
polymer
Article
differential scanning calorimetry
drug diffusion
drug formulation
drug penetration
drug release
drug solubility
glass transition temperature
in vitro study
investigative procedures
stress
tensile stress
Young modulus
biomechanics
chemistry
medicinal chemistry
metabolism
tensile strength
X ray diffraction
Biomechanical Phenomena
Chemistry, Pharmaceutical
Drug Liberation
Plasticizers
Polymers
Tensile Strength
X-Ray Diffraction
วันที่เผยแพร่: 2016
บทคัดย่อ: The objective of this study was to investigate thermal and mechanical properties as well as in vitro drug release of Eudragit® RL (ERL) film using chlorpheniramine maleate (CPM) as either active pharmaceutical ingredient or non-traditional plasticizer. Differential scanning calorimeter was used to measure the glass transition temperature (Tg) of 0-100% w/w CPM in ERL physical mixture. Instron testing machine was used to investigate Young's modulus, tensile stress and tensile strain (%) of ERL film containing 20-60% w/w CPM. Finally, a Franz diffusion cell was used to study drug release from ERL films obtained from four formulations, i.e. CRHP0/0, CRHP0/5, CRHP2/0 and CRHP2/5. The Tg of ERL was decreased when the weight percentage of CPM increased. The reduction of the Tg could be described by Kwei equation, indicating the interaction between CPM and ERL. Modulus and tensile stress decreased whereas tensile strain (%) increased when weight percentage of CPM increased. The change of mechanical properties was associated with the reduction of the Tg when weight percentage of CPM increased. ERL films obtained from four formulations could release the drug in no less than 10 h. Cumulative amount of drug release per unit area of ERL film containing only CPM (CRHP0/0) was lower than those obtained from the formulations containing traditional plasticizer (CRHP0/5), surfactant (CRHP2/0) or both of them (CRHP2/5). The increase of drug release was a result of the increase of drug permeability through ERL film and drug solubility based on traditional plasticizer and surfactant, respectively. © 2015 Taylor & Francis.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13573
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964330168&doi=10.3109%2f03639045.2015.1062513&partnerID=40&md5=a69af910a4750a6230542dc93fd81358
ISSN: 3639045
Appears in Collections:Scopus 1983-2021

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