Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13567
ชื่อเรื่อง: Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?
ผู้แต่ง: Timudom K.
Phothong N.
Akaraviputh T.
Chinswangwatanakul V.
Pongpaibul A.
Petsuksiri J.
Ithimakin S.
Trakarnsanga A.
Keywords: antineoplastic agent
adjuvant chemoradiotherapy
adult
advanced cancer
anastomosis leakage
Article
cancer chemotherapy
cancer radiotherapy
cancer surgery
female
histopathology
human
lymph vessel metastasis
major clinical study
male
middle aged
outcome assessment
peroperative complication
postoperative complication
radical resection
rectum cancer
retrospective study
Thailand
treatment indication
wound infection
วันที่เผยแพร่: 2016
บทคัดย่อ: Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extending the waiting time of surgery after neoadjuvant chemoradiation and perioperative outcomes. Methods. Sixty patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiation followed by radical resection at Siriraj hospital between June 2012 and January 2015 were retrospectively analyzed. Demographic data and perioperative outcomes were compared between the two groups. Results. The two groups were comparable in term of demographic parameters. The mean time interval from neoadjuvant chemoradiation to surgery was 6.4 weeks in Group A and 11.7 weeks in Group B. The perioperative outcomes were not significantly different between Groups A and B. Pathologic examination showed a significantly higher rate of circumferential margin positivity in Group A than in Group B (30% versus 9.3%, resp.; P = 0.04). Conclusions. Extending the waiting to >8 weeks from neoadjuvant chemoradiation to surgery did not increase perioperative complications, whereas the rate of circumferential margin positivity decreased. © 2016 Kittinut Timudom et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13567
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84990852977&doi=10.1155%2f2016%2f7870815&partnerID=40&md5=486a3ebee9c7f80579ee4667ad300c8f
ISSN: 16876121
Appears in Collections:Scopus 1983-2021

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