Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13557
ชื่อเรื่อง: Matrix metalloproteinase-9 expression is a marker of aggressive esophageal carcinoma: A meta-analysis [«L’espressione della matrice di metalloproteinasi-9 è un marcatore del carcinoma aggressivo esofageo: Una meta-analisi»]
ผู้แต่ง: Tullavardhana T.
Akranurakkul P.
Ungkitphaiboon W.
Songtish D.
Keywords: gelatinase B
tumor marker
aggressiveness
Article
cancer patient
cancer staging
cancer tissue
clinical feature
data base
esophagus biopsy
esophagus carcinoma
esophagus tissue
genetic association
histopathology
human
immunochemistry
immunohistochemistry
lymph node metastasis
lymph vessel metastasis
meta analysis
meta analysis (topic)
Newcastle-Ottawa scale
protein expression
protein function
systematic review (topic)
tumor biopsy
tumor differentiation
tumor invasion
วันที่เผยแพร่: 2016
บทคัดย่อ: Background: Matrix metalloproteinase-9 (MMP-9) is the proteolytic enzyme which degrades type IV collagen in basement membrane causing tumor invasion and metastasis. The purpose of the study is to evaluate whether MMP-9 expression is associated with the aggressiveness of esophageal carcinoma. Method: A search was performed on PubMed, EMBASE, Google scholar and the Cochrane database until March 2014. A meta-analysis was conducted to investigate the association between MMP-9 expression and the clinicopathological characteristics of esophageal cancer. Result: The final analysis included 673 esophageal cancer patients from 9 studies. MMP-9 expression was determined by the immunochemistry on biopsy or surgical specimens. The pooled data demonstrated that positive MMP-9 expression was significantly associated with poorer tumor differentiation (OR = 1.71, 95% CI: 1.13, 2.58; p = 0.01), lymph node metastasis (OR = 1.80, 95% CI: 1.20, 2.71; p = 0.005) and vascular invasion (OR = 2.55, 95% CI: 1.54, 4.21; p = 0.003). However, there were no significant associations between MMP-9 expression and advanced tumor staging, depth of tumor invasion and lymphatic invasion. Conclusion: The results of the meta-analysis strongly indicate that MMP-9 expression could function as a valuable marker for predicting the aggressiveness of esophageal cancer. © Mattioli 1885.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13557
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016450005&partnerID=40&md5=085dab677e71c84c4b2d99bb41b87158
ISSN: 11286598
Appears in Collections:Scopus 1983-2021

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