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Title: | Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant |
Authors: | Vongbhavit K. Underwood M.A. |
Keywords: | lactoferrin prebiotic agent probiotic agent synbiotic agent bacterial colonization bacterial genome breast milk dietary supplement disease association dysbiosis human intestine flora Lactobacillus necrotizing enterocolitis outcome assessment prematurity Review risk assessment risk factor Saccharomyces treatment response Enterocolitis, Necrotizing immunology infant newborn physiology Dysbiosis Enterocolitis, Necrotizing Gastrointestinal Microbiome Humans Infant Infant, Newborn Infant, Premature |
Issue Date: | 2016 |
Abstract: | Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated. © 2016 Elsevier HS Journals, Inc. All rights reserved. |
URI: | https://ir.swu.ac.th/jspui/handle/123456789/13448 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957927263&doi=10.1016%2fj.clinthera.2016.01.006&partnerID=40&md5=73b213b3f5b482b7b912b11ba37964f0 |
ISSN: | 1492918 |
Appears in Collections: | Scopus 1983-2021 |
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