Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13448
Title: Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant
Authors: Vongbhavit K.
Underwood M.A.
Keywords: lactoferrin
prebiotic agent
probiotic agent
synbiotic agent
bacterial colonization
bacterial genome
breast milk
dietary supplement
disease association
dysbiosis
human
intestine flora
Lactobacillus
necrotizing enterocolitis
outcome assessment
prematurity
Review
risk assessment
risk factor
Saccharomyces
treatment response
Enterocolitis, Necrotizing
immunology
infant
newborn
physiology
Dysbiosis
Enterocolitis, Necrotizing
Gastrointestinal Microbiome
Humans
Infant
Infant, Newborn
Infant, Premature
Issue Date: 2016
Abstract: Purpose In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Methods We review the evidence of an association between intestinal dysbiosis and NEC and summarize published English language clinical trials and cohort studies involving attempts to manipulate the intestinal microbiota in premature infants. Findings Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding. Implications Shaping the intestinal microbiota of the premature infant through human milk feeding and dietary supplements decreases the risk of NEC. Further studies to identify the ideal microbial composition and the most effective combination of supplements are indicated. © 2016 Elsevier HS Journals, Inc. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13448
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957927263&doi=10.1016%2fj.clinthera.2016.01.006&partnerID=40&md5=73b213b3f5b482b7b912b11ba37964f0
ISSN: 1492918
Appears in Collections:Scopus 1983-2021

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