Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13445
ชื่อเรื่อง: The anthelmintic effects of the ethanol extract of Terminalia catappa L. leaves against the ruminant gut parasite, Fischoederius cobboldi
ผู้แต่ง: Anuracpreeda P.
Chankaew K.
Puttarak P.
Koedrith P.
Chawengkirttikul R.
Panyarachun B.
Ngamniyom A.
Chanchai S.
Sobhon P.
Keywords: albendazole
anthelmintic agent
plant extract
Terminalia catappa extract
unclassified drug
albendazole
anthelmintic agent
plant extract
anthelmintic activity
Article
basement membrane
controlled study
drug effect
Fischoederius cobboldi
in vitro study
integument
microscopy
nonhuman
paramphistomosis
parasite
parasitosis
plant leaf
platyhelminth
priority journal
scanning electron microscopy
Terminalia
Terminalia catappa
trematode
animal
bovine
buffalo
chemistry
drug effects
movement (physiology)
parasitology
physiology
rumen
Terminalia
Trematode Infections
ultrastructure
veterinary
Albendazole
Animals
Anthelmintics
Buffaloes
Cattle
Microscopy, Electron, Scanning
Movement
Plant Extracts
Plant Leaves
Rumen
Terminalia
Trematoda
Trematode Infections
วันที่เผยแพร่: 2016
บทคัดย่อ: Presently, no effective anthelmintic drugs have been used to treat and control paramphistomosis, a severe disease of ruminants. In this study, we have investigated the in vitro anthelmintic effect of the leaves of Terminalia catappa L. crude extract (TcCE) and albendazole (ABZ) on adult Fischoederius cobboldi after incubating the flukes in RPMI-1640 medium containing the TcCE at various doses and times. The TcCE-treated flukes at all dosages exhibited rapid decrease of motility, and the relative motility (RM) values were decreased sharply from start to 3 h. Worms were killed after 6 and 12 h of treatment with 1000, 1500 and 2000 g mL-1 as well as 500 g mL-1 of TcCE, respectively. By light microscopy examination, the flukes exhibited the earliest alteration in a limited area of the tegument. At scanning electron microscopy level, the flukes' tegument showed similar sequence of morphological alterations after treatment with ABZ and TcCE that consisted of swelling of ridges and folds, followed by blebbing and rupturing of the blebs, leading to the erosion, lesion and disruption of the tegument. Hence, in vivo studies should be performed to examine whether the TcCE may serve as a powerful anthelmintic drug for treatment of paramphistomosis. © Cambridge University Press 2016.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13445
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961616828&doi=10.1017%2fS0031182015001833&partnerID=40&md5=14c7f56c4a43ba287f0ef30721abef9d
ISSN: 311820
Appears in Collections:Scopus 1983-2021

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