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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13432
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dc.contributor.authorKaruwanarint P.
dc.contributor.authorPhonrat B.
dc.contributor.authorTungtrongchitr A.
dc.contributor.authorSuriyaprom K.
dc.contributor.authorChuengsamarn S.
dc.contributor.authorSchweigert F.J.
dc.contributor.authorTungtrongchitr R.
dc.date.accessioned2021-04-05T03:23:55Z-
dc.date.available2021-04-05T03:23:55Z-
dc.date.issued2018
dc.identifier.issn17520363
dc.identifier.other2-s2.0-85046833886
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13432-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85046833886&doi=10.2217%2fbmm-2018-0029&partnerID=40&md5=0457478fa4a77ffbae253544f7ed5a4a
dc.description.abstractAim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-Type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais. © 2018 2018 Future Medicine Ltd.
dc.subjectglobulin
dc.subjectglucose
dc.subjectvitamin D binding protein
dc.subjectglobulin
dc.subjectvitamin D binding protein
dc.subjectadult
dc.subjectage distribution
dc.subjectaged
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgenetic association
dc.subjectgenetic susceptibility
dc.subjectgenetic variation
dc.subjectgenotype
dc.subjectglucose blood level
dc.subjectheterozygote
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectprotein analysis
dc.subjectprotein blood level
dc.subjectprotein polymorphism
dc.subjectrisk factor
dc.subjectsystolic blood pressure
dc.subjectThai (people)
dc.subjectWestern blotting
dc.subjectwild type
dc.subjectblood
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectmetabolic syndrome X
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectsingle nucleotide polymorphism
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGlobulins
dc.subjectHumans
dc.subjectMale
dc.subjectMetabolic Syndrome
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectVitamin D-Binding Protein
dc.titleVitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationBiomarkers in Medicine. Vol 12, No.5 (2018), p.465-473
dc.identifier.doi10.2217/bmm-2018-0029
Appears in Collections:Scopus 1983-2021

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