Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13430
ชื่อเรื่อง: Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis
ผู้แต่ง: Supasuteekul C.
Nonthitipong W.
Tadtong S.
Likhitwitayawuid K.
Tengamnuay P.
Sritularak B.
Keywords: 5 hydroxymethylfurfural
acarbose
alpha glucosidase
antioxidant
Garcinia gracilis extract
glucopyranoside
glucose
glycoside
methanol
neuroprotective agent
plant extract
protein p19
quercetin
rhamnose
riboflavin
trolox C
unclassified drug
vanillic acid
antioxidant activity
Article
biological activity
cell differentiation
cell isolation
cell viability
DNA damage
DPPH radical scavenging assay
drug potentiation
Garcinia
genetic linkage
growth curve
IC50
neuroprotection
oxidative stress
photooxidation
plant leaf
วันที่เผยแพร่: 2016
บทคัดย่อ: The leaves of Garcinia gracilis Pierre, Clusiaceae, have been used as flavouring materials in food, with no previous reports of their biological activities and chemical constituents. In this study, the methanolic extract of G. gracilis afforded three compounds namely apigenin-8-C-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (1), 5-hydroxymethyl-2-furaldehyde, and vanillic acid. All of the isolates were initially evaluated for superoxide anion radical scavenging activity and α-glucosidase inhibitory effects. Compound 1, which was the major component, showed the most potent activities among these three isolates. Further biological evaluations revealed that compound 1 could prevent the pBR322 plasmid DNA damage induced by the photochemical reaction of riboflavin and protect P19-derived neurons from the oxidative stress condition induced by serum deprivation. It was concluded that the potent biological activities of G. gracilis could be attributed to the synergistic effect of compound 1 with other constituents found in the plant. © 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13430
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975093399&doi=10.1016%2fj.bjp.2016.01.007&partnerID=40&md5=e3c643905d8f40c34b893f5408495d70
ISSN: 1981528X
Appears in Collections:Scopus 1983-2021

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