Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13409
ชื่อเรื่อง: Graphene-polyaniline modified electrochemical droplet-based microfluidic sensor for high-throughput determination of 4-aminophenol
ผู้แต่ง: Rattanarat P.
Suea-Ngam A.
Ruecha N.
Siangproh W.
Henry C.S.
Srisa-Art M.
Chailapakul O.
Keywords: Capillary electrophoresis
Carbon
Chemical detection
Drops
Drug products
Electrochemical electrodes
Electrodes
Electrophoresis
Graphene
Intersections
Polyaniline
Screening
Throughput
4-aminophenols
Capillary zone electrophoresis
Droplet-based microfluidics
ELectrochemical detection
Electrochemical measurements
High throughput screening
Modified carbon paste electrode
Paracetamol
Microfluidics
aminophenol
graphene
polyaniline
4-aminophenol
aminophenol derivative
aniline derivative
graphite
polyaniline
adsorption
Article
controlled study
cyclic potentiometry
dispersion
electrochemical detection
flow rate
high throughput screening
hydrodynamics
limit of detection
limit of quantitation
microfluidics
oxidation reduction potential
priority journal
sensitivity and specificity
signal noise ratio
chemistry
devices
electrochemical analysis
microfluidics
procedures
scanning electron microscopy
transmission electron microscopy
Aminophenols
Aniline Compounds
Electrochemical Techniques
Graphite
High-Throughput Screening Assays
Microfluidics
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
วันที่เผยแพร่: 2016
บทคัดย่อ: We report herein the first development of graphene-polyaniline modified carbon paste electrode (G-PANI/CPE) coupled with droplet-based microfluidic sensor for high-throughput detection of 4-aminophenol (4-AP) in pharmaceutical paracetamol (PA) formulations. A simple T-junction microfluidic platform using an oil flow rate of 1.8 μL/min and an aqueous flow rate of 0.8 μL/min was used to produce aqueous testing microdroplets continuously. The microchannel was designed to extend the aqueous droplet to cover all 3 electrodes, allowing for electrochemical measurements in a single droplet. Parameters including flow rate, water fraction, and applied detection potential (Edet) were investigated to obtain optimal conditions. Using G-PANI/CPE significantly increased the current response for both cyclic voltammetric detections of ferri/ferrocyanide [Fe(CN)6]3-/4- (10 times) and 4-AP (2 times), compared to an unmodified electrode. Using the optimized conditions in the droplet system, 4-AP in the presence of PA was selectively determined. The linear range of 4-AP was 50-500 μM (R2 = 0.99), limit of detection (LOD, S/N = 3) was 15.68 μM, and limit of quantification (LOQ, S/N = 10) was 52.28 μM. Finally, the system was used to determine 4-AP spiked in commercial PA liquid samples and the amounts of 4-AP were found in good agreement with those obtained from the conventional capillary zone electrophoresis/UV-Visible spectrophotometry (CZE/UV-Vis). The proposed microfluidic device could be employed for a high-throughput screening (at least 60 samples h-1) of pharmaceutical purity requiring low sample and reagent consumption. © 2016 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13409
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84966473932&doi=10.1016%2fj.aca.2016.03.010&partnerID=40&md5=27e298f44eaace2249e9fedb54ccbdae
ISSN: 32670
Appears in Collections:Scopus 1983-2021

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