Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13370
ชื่อเรื่อง: Impact of Neoadjuvant Chemoradiation on Short-Term Outcomes for Esophageal Squamous Cell Carcinoma Patients: A Meta-analysis
ผู้แต่ง: Sathornviriyapong S.
Matsuda A.
Miyashita M.
Matsumoto S.
Sakurazawa N.
Kawano Y.
Yamada M.
Uchida E.
Keywords: adjuvant chemoradiotherapy
anastomosis
Article
cancer patient
clinical decision making
esophageal squamous cell carcinoma
esophagus resection
heart disease
human
meta analysis
morbidity
outcome assessment
patient dropout
postoperative complication
randomized controlled trial (topic)
respiratory tract disease
surgical mortality
systematic review
adjuvant chemoradiotherapy
esophagus tumor
heart disease
lung disease
mortality
neoadjuvant therapy
postoperative complication
squamous cell carcinoma
survival rate
time factor
treatment outcome
Carcinoma, Squamous Cell
Chemoradiotherapy, Adjuvant
Esophageal Neoplasms
Esophagectomy
Heart Diseases
Humans
Lung Diseases
Neoadjuvant Therapy
Patient Dropouts
Postoperative Complications
Randomized Controlled Trials as Topic
Survival Rate
Time Factors
Treatment Outcome
วันที่เผยแพร่: 2016
บทคัดย่อ: Background: Neoadjuvant chemoradiation (NCRT) has emerged as a component of the standard treatment for esophageal squamous cell carcinoma (SCC). The primary benefit of NCRT is an improvement in long-term survival; however, the impact of NCRT on short-term outcomes is unclear. Methods: A comprehensive electronic literature search was performed via the MEDLINE (PubMed), Cochrane Library, and Google Scholar databases through November 2015 for the inclusion of randomized controlled trials (RCTs) that evaluated short-term outcomes of patients administered NCRT followed by surgery compared with surgery alone for resectable esophageal SCC. The main outcome measures were postoperative mortality and morbidity. A meta-analysis was performed using random-effects models to calculate odds ratios (ORs) with 95 % confidence intervals (CIs). Results: Eight RCTs were included, for a total of 1058 patients. Meta-analysis of the overall postoperative mortality and cardiopulmonary complication rates showed that there was a significant increase for patients administered NCRT followed by surgery compared with surgery alone (OR 1.87, 95 % CI 1.07–3.28, p = 0.03, number of patients needed to harm = 33.3; and OR 2.12, 95 % CI 1.03–4.35, p = 0.04, respectively). Dropout before surgery was higher for patients in the NCRT followed by surgery group compared with patients in the surgery-alone group. NCRT has no statistically impact on anastomosis and other complications compared with surgery alone. Conclusions: NCRT for esophageal SCC significantly increases postoperative mortality and cardiopulmonary complications. © 2016, Society of Surgical Oncology.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13370
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976292383&doi=10.1245%2fs10434-016-5298-9&partnerID=40&md5=1bc0487a904892821144c6c64ada75a0
ISSN: 10689265
Appears in Collections:Scopus 1983-2021

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