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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13361
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dc.contributor.authorLaffleur F.
dc.contributor.authorZilio M.
dc.contributor.authorShuwisitkul D.
dc.date.accessioned2021-04-05T03:23:30Z-
dc.date.available2021-04-05T03:23:30Z-
dc.date.issued2016
dc.identifier.issn20415990
dc.identifier.other2-s2.0-84994152086
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13361-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994152086&doi=10.4155%2ftde-2016-0046&partnerID=40&md5=91cb891f84d0ec1c5d23949d515caff7
dc.description.abstractAim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. Methods: Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. Results: The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. Conclusion: Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery. © 2016 Future Science Ltd.
dc.subjectcysteine
dc.subjectdisulfide
dc.subjectdoxepin
dc.subjectpectin
dc.subjectdoxepin
dc.subjectdrug carrier
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcell viability
dc.subjectcheek mucosa
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdisulfide bond
dc.subjectdrug delivery system
dc.subjectgravimetry
dc.subjectinfrared spectroscopy
dc.subjectmucoadhesion
dc.subjectnonhuman
dc.subjectpH
dc.subjectpolymerization
dc.subjectpriority journal
dc.subjectresazurin assay
dc.subjectsurface property
dc.subjectsustained drug release
dc.subjectsynthesis
dc.subjectadhesion
dc.subjectbuccal drug administration
dc.subjectcell culture
dc.subjectcell survival
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectdrug release
dc.subjectdrug stability
dc.subjecthuman
dc.subjectmouth mucosa
dc.subjectAdhesiveness
dc.subjectAdministration, Buccal
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectCysteine
dc.subjectDoxepin
dc.subjectDrug Carriers
dc.subjectDrug Liberation
dc.subjectDrug Stability
dc.subjectHumans
dc.subjectMouth Mucosa
dc.subjectPectins
dc.titleModified biomolecule as potential vehicle for buccal delivery of doxepin
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationTherapeutic Delivery. Vol 7, No.10 (2016), p.683-689
dc.identifier.doi10.4155/tde-2016-0046
Appears in Collections:Scopus 1983-2021

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