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https://ir.swu.ac.th/jspui/handle/123456789/13361| Title: | Modified biomolecule as potential vehicle for buccal delivery of doxepin |
| Authors: | Laffleur F. Zilio M. Shuwisitkul D. |
| Keywords: | cysteine disulfide doxepin pectin doxepin drug carrier animal tissue Article cell viability cheek mucosa comparative study controlled study disulfide bond drug delivery system gravimetry infrared spectroscopy mucoadhesion nonhuman pH polymerization priority journal resazurin assay surface property sustained drug release synthesis adhesion buccal drug administration cell culture cell survival chemistry drug effects drug release drug stability human mouth mucosa Adhesiveness Administration, Buccal Cell Survival Cells, Cultured Cysteine Doxepin Drug Carriers Drug Liberation Drug Stability Humans Mouth Mucosa Pectins |
| Issue Date: | 2016 |
| Abstract: | Aim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. Methods: Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. Results: The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. Conclusion: Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery. © 2016 Future Science Ltd. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13361 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994152086&doi=10.4155%2ftde-2016-0046&partnerID=40&md5=91cb891f84d0ec1c5d23949d515caff7 |
| ISSN: | 20415990 |
| Appears in Collections: | Scopus 1983-2021 |
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