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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13308
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dc.contributor.authorPrachayasittikul S.
dc.contributor.authorPingaew R.
dc.contributor.authorWorachartcheewan A.
dc.contributor.authorSinthupoom N.
dc.contributor.authorPrachayasittikul V.
dc.contributor.authorRuchirawat S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T03:23:12Z-
dc.date.available2021-04-05T03:23:12Z-
dc.date.issued2017
dc.identifier.issn13895575
dc.identifier.other2-s2.0-85025119431
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13308-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85025119431&doi=10.2174%2f1389557516666160923125801&partnerID=40&md5=8579905d52458c712981439463f18b4a
dc.description.abstractBackground: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing drugs have driven the search for novel anticancer drugs with better potency and selectivity, improved pharmacokinetic profiles, and minimum toxicities. Pyridine and pyrimidine are presented in natural products and genetic materials. These pyridine/pyrimidine core structures have been noted for their roles in many biological processes as well as in cancer pathogenesis, which make such compounds become attractive scaffolds for discovery of novel drugs. Results & Conclusion: In the recent years, pyridine- and pyrimidine-based anticancer drugs have been developed based on structural modification of these core structures (i.e., substitution with moieties and rings, conjugation with other compounds, and coordination with metal ions). Detailed discussion is provided in this review to highlight the potential of these small molecules as privileged scaffolds with attractive properties and biological activities for the search of novel anticancer agents. © 2017 Bentham Science Publishers.
dc.subject1,2,3 triazole derivative
dc.subject1,4 naphthoquinone
dc.subject2,4 diphenoxy 6 aryl pyridine
dc.subject2,4 diphenoxy pyridine
dc.subject2,4 diphenoxyl 6 heteroaryl pyridine
dc.subject2,4 diphenyl 6 aryl pyridine
dc.subject2,4 diphenyl 6 heteroaryl pyridine
dc.subject2,4,6 triheteroaryl pyridine
dc.subject2,4,6 triphenyl pyridine
dc.subject2,6 diaminopyridine
dc.subject2,6 diphenyl 4 heteroaryl pyridine
dc.subject3 aminopicolinaldehyde thiosemicarbazone
dc.subject3 aminopyridine thiosemicarbazone
dc.subject3,5 disubstituted pyridine
dc.subject4 chromanone derivative
dc.subjectanthranilic acid
dc.subjectantineoplastic agent
dc.subjectcoumarin
dc.subjectdoxorubicin
dc.subjectisoflavone
dc.subjectnicotinamide
dc.subjectpicoline derivative
dc.subjectpyridine derivative
dc.subjectpyrimidine derivative
dc.subjectquinoline
dc.subjectribonucleotide reductase
dc.subjecttetrahydroisoquinoline
dc.subjectthiadiazole derivative
dc.subjectthiosemicarbazone derivative
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectantineoplastic agent
dc.subjectpyridine derivative
dc.subjectpyrimidine derivative
dc.subjectA-549 cell line
dc.subjectantineoplastic activity
dc.subjectantiproliferative activity
dc.subjectapoptosis
dc.subjectbreast cancer
dc.subjectcancer cell
dc.subjectcancer therapy
dc.subjectcell growth
dc.subjectcell survival
dc.subjectchronic myeloid leukemia
dc.subjectcolorectal cancer
dc.subjectDNA repair
dc.subjecterectile dysfunction
dc.subjectHep-G2 cell line
dc.subjectIC50
dc.subjectkidney carcinoma
dc.subjectneoplasm
dc.subjectnon small cell lung cancer
dc.subjectnonhuman
dc.subjectprostate cancer
dc.subjectquality of life
dc.subjectReview
dc.subjecttumor suppressor gene
dc.subjectchemistry
dc.subjectDNA damage
dc.subjectdrug effects
dc.subjecthuman
dc.subjectstructure activity relation
dc.subjectsynthesis
dc.subjectAntineoplastic Agents
dc.subjectCell Survival
dc.subjectDNA Damage
dc.subjectHumans
dc.subjectPyridines
dc.subjectPyrimidines
dc.subjectStructure-Activity Relationship
dc.titleRoles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents
dc.typeReview
dc.rights.holderScopus
dc.identifier.bibliograpycitationMini-Reviews in Medicinal Chemistry. Vol 17, No.10 (2017), p.869-901
dc.identifier.doi10.2174/1389557516666160923125801
Appears in Collections:Scopus 1983-2021

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