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https://ir.swu.ac.th/jspui/handle/123456789/13308| Title: | Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents |
| Authors: | Prachayasittikul S. Pingaew R. Worachartcheewan A. Sinthupoom N. Prachayasittikul V. Ruchirawat S. Prachayasittikul V. |
| Keywords: | 1,2,3 triazole derivative 1,4 naphthoquinone 2,4 diphenoxy 6 aryl pyridine 2,4 diphenoxy pyridine 2,4 diphenoxyl 6 heteroaryl pyridine 2,4 diphenyl 6 aryl pyridine 2,4 diphenyl 6 heteroaryl pyridine 2,4,6 triheteroaryl pyridine 2,4,6 triphenyl pyridine 2,6 diaminopyridine 2,6 diphenyl 4 heteroaryl pyridine 3 aminopicolinaldehyde thiosemicarbazone 3 aminopyridine thiosemicarbazone 3,5 disubstituted pyridine 4 chromanone derivative anthranilic acid antineoplastic agent coumarin doxorubicin isoflavone nicotinamide picoline derivative pyridine derivative pyrimidine derivative quinoline ribonucleotide reductase tetrahydroisoquinoline thiadiazole derivative thiosemicarbazone derivative unclassified drug unindexed drug antineoplastic agent pyridine derivative pyrimidine derivative A-549 cell line antineoplastic activity antiproliferative activity apoptosis breast cancer cancer cell cancer therapy cell growth cell survival chronic myeloid leukemia colorectal cancer DNA repair erectile dysfunction Hep-G2 cell line IC50 kidney carcinoma neoplasm non small cell lung cancer nonhuman prostate cancer quality of life Review tumor suppressor gene chemistry DNA damage drug effects human structure activity relation synthesis Antineoplastic Agents Cell Survival DNA Damage Humans Pyridines Pyrimidines Structure-Activity Relationship |
| Issue Date: | 2017 |
| Abstract: | Background: Cancer has been considered to be a global health concern due to the impact of disease on the quality of life. The continual increase of cancer cases as well as the resistance of cancer cells to the existing drugs have driven the search for novel anticancer drugs with better potency and selectivity, improved pharmacokinetic profiles, and minimum toxicities. Pyridine and pyrimidine are presented in natural products and genetic materials. These pyridine/pyrimidine core structures have been noted for their roles in many biological processes as well as in cancer pathogenesis, which make such compounds become attractive scaffolds for discovery of novel drugs. Results & Conclusion: In the recent years, pyridine- and pyrimidine-based anticancer drugs have been developed based on structural modification of these core structures (i.e., substitution with moieties and rings, conjugation with other compounds, and coordination with metal ions). Detailed discussion is provided in this review to highlight the potential of these small molecules as privileged scaffolds with attractive properties and biological activities for the search of novel anticancer agents. © 2017 Bentham Science Publishers. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13308 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025119431&doi=10.2174%2f1389557516666160923125801&partnerID=40&md5=8579905d52458c712981439463f18b4a |
| ISSN: | 13895575 |
| Appears in Collections: | Scopus 1983-2021 |
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