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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13307
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dc.contributor.authorVongbhavit K.
dc.contributor.authorUnderwood M.A.
dc.date.accessioned2021-04-05T03:23:11Z-
dc.date.available2021-04-05T03:23:11Z-
dc.date.issued2017
dc.identifier.issn19345798
dc.identifier.other2-s2.0-85031823237
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13307-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031823237&doi=10.3233%2fNPM-16148&partnerID=40&md5=e4551ea4c3aae244947c9dcc47cea793
dc.description.abstractOBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week). RESULTS: 130 premature infants were included, 30 infants with SIP, 35 infants with sNEC and 65 control infants. The median age of onset was 5 days postnatal age in SIP versus 25 days in sNEC (p < 0.001) and the peak onset was at 26 weeks correctedGAfor SIP and 30 weeks correctedGAfor sNEC. Infants with perforation had significantly higher rates of mortality (p < 0.001) and common morbidities associated with prematurity. Administration of corticosteroids and indomethacin did not differ among groups. SIP was more common among infants born to young mothers (p = 0.04) and less common in infants receiving caffeine (p = 0.02). sNECwas less common among infants receiving early red cell transfusion (p = 0.01). Perforation and sNEC trended towards less common in infants receiving inhaled nitric oxide. CONCLUSION: SIP and sNEC are distinct clinical entities. Potential protective effects of caffeine, inhaled nitric oxide, and early transfusion should be further studied. © 2017 IOS Press and the authors. All rights reserved.
dc.subjectantifungal agent
dc.subjectC reactive protein
dc.subjectcaffeine
dc.subjectcorticosteroid
dc.subjectglycerol
dc.subjectindometacin
dc.subjectnitric oxide
dc.subjectendothelium derived relaxing factor
dc.subjectnitric oxide
dc.subjectApgar score
dc.subjectArticle
dc.subjectbirth weight
dc.subjectbody weight
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjecterythrocyte transfusion
dc.subjectgestational age
dc.subjecthead circumference
dc.subjecthospitalization
dc.subjecthuman
dc.subjecthypertension
dc.subjectincidence
dc.subjectinfant
dc.subjectlength of stay
dc.subjectmajor clinical study
dc.subjectmorbidity
dc.subjectmortality
dc.subjectnecrotizing enterocolitis
dc.subjectonset age
dc.subjectprematurity
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectsmall intestine perforation
dc.subjectspontaneous ileal perforation
dc.subjectspontaneous ileal perforation
dc.subjectspontaneous perforation
dc.subjectsurgical necrotizing enterocolitis
dc.subjectsurgical necrotizing enterocolitis
dc.subjectadult
dc.subjectcohort analysis
dc.subjectenterostomy
dc.subjectfemale
dc.subjecthypertension
dc.subjectileum disease
dc.subjectinhalational drug administration
dc.subjectintestine perforation
dc.subjectlow birth weight
dc.subjectmale
dc.subjectmaternal age
dc.subjectnecrotizing enterocolitis
dc.subjectnewborn
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectprematurity
dc.subjectrisk factor
dc.subjectrupture
dc.subjectyoung adult
dc.subjectAdministration, Inhalation
dc.subjectAdult
dc.subjectAge of Onset
dc.subjectCase-Control Studies
dc.subjectCohort Studies
dc.subjectEndothelium-Dependent Relaxing Factors
dc.subjectEnterocolitis, Necrotizing
dc.subjectEnterostomy
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectIleal Diseases
dc.subjectInfant, Extremely Premature
dc.subjectInfant, Low Birth Weight
dc.subjectInfant, Newborn
dc.subjectInfant, Premature
dc.subjectIntestinal Perforation
dc.subjectMale
dc.subjectMaternal Age
dc.subjectNitric Oxide
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectRupture, Spontaneous
dc.subjectYoung Adult
dc.titleIntestinal perforation in the premature infant
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Neonatal-Perinatal Medicine. Vol 10, No.3 (2017), p.281-289
dc.identifier.doi10.3233/NPM-16148
Appears in Collections:Scopus 1983-2021

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