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https://ir.swu.ac.th/jspui/handle/123456789/13307| Title: | Intestinal perforation in the premature infant |
| Authors: | Vongbhavit K. Underwood M.A. |
| Keywords: | antifungal agent C reactive protein caffeine corticosteroid glycerol indometacin nitric oxide endothelium derived relaxing factor nitric oxide Apgar score Article birth weight body weight case control study controlled study erythrocyte transfusion gestational age head circumference hospitalization human hypertension incidence infant length of stay major clinical study morbidity mortality necrotizing enterocolitis onset age prematurity priority journal retrospective study small intestine perforation spontaneous ileal perforation spontaneous ileal perforation spontaneous perforation surgical necrotizing enterocolitis surgical necrotizing enterocolitis adult cohort analysis enterostomy female hypertension ileum disease inhalational drug administration intestine perforation low birth weight male maternal age necrotizing enterocolitis newborn pregnancy pregnancy complication prematurity risk factor rupture young adult Administration, Inhalation Adult Age of Onset Case-Control Studies Cohort Studies Endothelium-Dependent Relaxing Factors Enterocolitis, Necrotizing Enterostomy Female Humans Hypertension Ileal Diseases Infant, Extremely Premature Infant, Low Birth Weight Infant, Newborn Infant, Premature Intestinal Perforation Male Maternal Age Nitric Oxide Pregnancy Pregnancy Complications Retrospective Studies Risk Factors Rupture, Spontaneous Young Adult |
| Issue Date: | 2017 |
| Abstract: | OBJECTIVE: To compare demographic data, prenatal and postnatal characteristics, laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal perforation (SIP), surgical necrotizing enterocolitis (sNEC) and matched controls. METHODS: A retrospective case-control study of infants with intestinal perforation with a birth weight (BW) less than 2,000 grams and gestational age (GA) less than 34 weeks and infants without perforation matched for BW (±150 grams) and GA (±1week). RESULTS: 130 premature infants were included, 30 infants with SIP, 35 infants with sNEC and 65 control infants. The median age of onset was 5 days postnatal age in SIP versus 25 days in sNEC (p < 0.001) and the peak onset was at 26 weeks correctedGAfor SIP and 30 weeks correctedGAfor sNEC. Infants with perforation had significantly higher rates of mortality (p < 0.001) and common morbidities associated with prematurity. Administration of corticosteroids and indomethacin did not differ among groups. SIP was more common among infants born to young mothers (p = 0.04) and less common in infants receiving caffeine (p = 0.02). sNECwas less common among infants receiving early red cell transfusion (p = 0.01). Perforation and sNEC trended towards less common in infants receiving inhaled nitric oxide. CONCLUSION: SIP and sNEC are distinct clinical entities. Potential protective effects of caffeine, inhaled nitric oxide, and early transfusion should be further studied. © 2017 IOS Press and the authors. All rights reserved. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13307 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031823237&doi=10.3233%2fNPM-16148&partnerID=40&md5=e4551ea4c3aae244947c9dcc47cea793 |
| ISSN: | 19345798 |
| Appears in Collections: | Scopus 1983-2021 |
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