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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13297
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dc.contributor.authorAwale S.
dc.contributor.authorTawila A.M.
dc.contributor.authorDibwe D.F.
dc.contributor.authorUeda J.-Y.
dc.contributor.authorSun S.
dc.contributor.authorAthikomkulchai S.
dc.contributor.authorBalachandran C.
dc.contributor.authorSaiki I.
dc.contributor.authorMatsumoto K.
dc.contributor.authorEsumi H.
dc.date.accessioned2021-04-05T03:23:09Z-
dc.date.available2021-04-05T03:23:09Z-
dc.date.issued2017
dc.identifier.issn0960894X
dc.identifier.other2-s2.0-85015942234
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13297-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85015942234&doi=10.1016%2fj.bmcl.2017.03.021&partnerID=40&md5=5984c6328985a72cbb5aeb226472c166
dc.description.abstractFrom the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd
dc.subjectantineoplastic agent
dc.subjectcyclohexene derivative
dc.subjectunclassified drug
dc.subjectuvaridacol i
dc.subjectuvaridacol j
dc.subjectuvaridacol k
dc.subjectuvaridacol l
dc.subjectantineoplastic agent
dc.subjectcyclohexene
dc.subjectcyclohexene derivative
dc.subjectoxygen
dc.subjectArticle
dc.subjectCapan 1 cell line
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcircular dichroism
dc.subjectcytotoxicity
dc.subjectdrug potency
dc.subjectheteronuclear multiple bond correlation
dc.subjecthuman
dc.subjecthuman cell
dc.subjectKLM 1 cell line
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectnuclear Overhauser effect
dc.subjectPaCa 2 cell line
dc.subjectPANC 1 cell line
dc.subjectpancreatic cancer cell line
dc.subjectplant leaf
dc.subjectproton nuclear magnetic resonance
dc.subjectPSN 1 cell line
dc.subjectUvaria
dc.subjectUvaria dac
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectdrug screening
dc.subjectisolation and purification
dc.subjectpancreas
dc.subjectPancreatic Neoplasms
dc.subjectplant leaf
dc.subjecttumor cell line
dc.subjectUvaria
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectCell Line, Tumor
dc.subjectCyclohexenes
dc.subjectDrug Screening Assays, Antitumor
dc.subjectHumans
dc.subjectOxygen
dc.subjectPancreas
dc.subjectPancreatic Neoplasms
dc.subjectPlant Leaves
dc.subjectUvaria
dc.titleHighly oxygenated antiausterity agents from the leaves of Uvaria dac
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationBioorganic and Medicinal Chemistry Letters. Vol 27, No.9 (2017), p.1967-1971
dc.identifier.doi10.1016/j.bmcl.2017.03.021
Appears in Collections:Scopus 1983-2021

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