Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13297
ชื่อเรื่อง: Highly oxygenated antiausterity agents from the leaves of Uvaria dac
ผู้แต่ง: Awale S.
Tawila A.M.
Dibwe D.F.
Ueda J.-Y.
Sun S.
Athikomkulchai S.
Balachandran C.
Saiki I.
Matsumoto K.
Esumi H.
Keywords: antineoplastic agent
cyclohexene derivative
unclassified drug
uvaridacol i
uvaridacol j
uvaridacol k
uvaridacol l
antineoplastic agent
cyclohexene
cyclohexene derivative
oxygen
Article
Capan 1 cell line
carbon nuclear magnetic resonance
circular dichroism
cytotoxicity
drug potency
heteronuclear multiple bond correlation
human
human cell
KLM 1 cell line
nuclear magnetic resonance spectroscopy
nuclear Overhauser effect
PaCa 2 cell line
PANC 1 cell line
pancreatic cancer cell line
plant leaf
proton nuclear magnetic resonance
PSN 1 cell line
Uvaria
Uvaria dac
chemistry
drug effects
drug screening
isolation and purification
pancreas
Pancreatic Neoplasms
plant leaf
tumor cell line
Uvaria
Antineoplastic Agents, Phytogenic
Cell Line, Tumor
Cyclohexenes
Drug Screening Assays, Antitumor
Humans
Oxygen
Pancreas
Pancreatic Neoplasms
Plant Leaves
Uvaria
วันที่เผยแพร่: 2017
บทคัดย่อ: From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd
URI: https://ir.swu.ac.th/jspui/handle/123456789/13297
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015942234&doi=10.1016%2fj.bmcl.2017.03.021&partnerID=40&md5=5984c6328985a72cbb5aeb226472c166
ISSN: 0960894X
Appears in Collections:Scopus 1983-2021

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