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https://ir.swu.ac.th/jspui/handle/123456789/13297| Title: | Highly oxygenated antiausterity agents from the leaves of Uvaria dac |
| Authors: | Awale S. Tawila A.M. Dibwe D.F. Ueda J.-Y. Sun S. Athikomkulchai S. Balachandran C. Saiki I. Matsumoto K. Esumi H. |
| Keywords: | antineoplastic agent cyclohexene derivative unclassified drug uvaridacol i uvaridacol j uvaridacol k uvaridacol l antineoplastic agent cyclohexene cyclohexene derivative oxygen Article Capan 1 cell line carbon nuclear magnetic resonance circular dichroism cytotoxicity drug potency heteronuclear multiple bond correlation human human cell KLM 1 cell line nuclear magnetic resonance spectroscopy nuclear Overhauser effect PaCa 2 cell line PANC 1 cell line pancreatic cancer cell line plant leaf proton nuclear magnetic resonance PSN 1 cell line Uvaria Uvaria dac chemistry drug effects drug screening isolation and purification pancreas Pancreatic Neoplasms plant leaf tumor cell line Uvaria Antineoplastic Agents, Phytogenic Cell Line, Tumor Cyclohexenes Drug Screening Assays, Antitumor Humans Oxygen Pancreas Pancreatic Neoplasms Plant Leaves Uvaria |
| Issue Date: | 2017 |
| Abstract: | From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1–4) were isolated together with nine previously reported compounds (5–13). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM). © 2017 Elsevier Ltd |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/13297 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015942234&doi=10.1016%2fj.bmcl.2017.03.021&partnerID=40&md5=5984c6328985a72cbb5aeb226472c166 |
| ISSN: | 0960894X |
| Appears in Collections: | Scopus 1983-2021 |
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