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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13289
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dc.contributor.authorChittasupho C.
dc.contributor.authorKewsuwan P.
dc.contributor.authorMurakami T.
dc.date.accessioned2021-04-05T03:23:07Z-
dc.date.available2021-04-05T03:23:07Z-
dc.date.issued2017
dc.identifier.issn15672018
dc.identifier.other2-s2.0-85041060602
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13289-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041060602&doi=10.2174%2f1567201814666170216130448&partnerID=40&md5=cfe5aa097f88c55457c776568f239402
dc.description.abstractBackground: CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell. Objective: In this study, CXCR4 targeted polymeric nanoparticle was developed for delivering cytotoxic drug and blocking the chemokine induced migration of cells expressing CXCR4. Method: A peptide which was a linear form of CXCR4 antagonist (LFC131) was attached to PLGA nanoparticles (LFC131-NPs) and PLGA nanoparticles encapsulating DOX (LFC131-DOX-NPs). The cellular binding and internalization of LFC131-DOX-NPs were investigated. Results: The binding and internalization of LFC131-DOX-NPs were higher and more rapidly compared to unconjugated NPs. LFC131-NPs blocked SDF-1α induced migration of BT-549-Luc cells. MTT assays demonstrated that LFC131-NPs and LFC131-DOX-NPs decreased cell viability in a dose dependent manner in 24, 72 and 120 h incubation. Conclusion: A treatment concept of blocking breast cancer cell migration from interaction with SDF- 1α by using LFC131-NPs and then attacking breast cancer cells with doxorubicin might increase the efficacy of current breast cancer treatment. © 2017 Bentham Science Publishers.
dc.subjectchemokine
dc.subjectchemokine receptor CXCR4 antagonist
dc.subjectcytotoxic agent
dc.subjectdoxorubicin
dc.subjectlfc 131
dc.subjectnanoparticle
dc.subjectpolyglactin
dc.subjectstromal cell derived factor 1alpha
dc.subjecttyrosinylarginylarginine sodium iodide glycine
dc.subjectunclassified drug
dc.subjectantineoplastic antibiotic
dc.subjectchemokine receptor CXCR4
dc.subjectCXCL12 protein, human
dc.subjectCXCR4 protein, human
dc.subjectdoxorubicin
dc.subjectlactic acid
dc.subjectligand
dc.subjectnanoparticle
dc.subjectoligopeptide
dc.subjectpolyglycolic acid
dc.subjectpolylactic acid-polyglycolic acid copolymer
dc.subjectstromal cell derived factor 1
dc.subjectapoptosis
dc.subjectArticle
dc.subjectbreast cancer cell line
dc.subjectBT 549 Luc cell line
dc.subjectcancer chemotherapy
dc.subjectcell migration
dc.subjectcell viability
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug delivery system
dc.subjectdrug efficacy
dc.subjectdrug protein binding
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectincubation time
dc.subjectinternalization
dc.subjectMTT assay
dc.subjectpriority journal
dc.subjectantagonists and inhibitors
dc.subjectapoptosis
dc.subjectbreast tumor
dc.subjectcell motion
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectmetabolism
dc.subjectpathology
dc.subjecttumor cell culture
dc.subjectAntibiotics, Antineoplastic
dc.subjectApoptosis
dc.subjectBreast Neoplasms
dc.subjectCell Movement
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectChemokine CXCL12
dc.subjectDoxorubicin
dc.subjectDrug Screening Assays, Antitumor
dc.subjectHumans
dc.subjectLactic Acid
dc.subjectLigands
dc.subjectNanoparticles
dc.subjectOligopeptides
dc.subjectPolyglycolic Acid
dc.subjectReceptors, CXCR4
dc.subjectTumor Cells, Cultured
dc.titleCXCR4-targeted nanoparticles reduce cell viability, induce apoptosis and inhibit SDF-1α induced BT-549-Luc cell migration in vitro
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationCurrent Drug Delivery. Vol 14, No.8 (2017), p.1060-1070
dc.identifier.doi10.2174/1567201814666170216130448
Appears in Collections:Scopus 1983-2021

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