Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13277
ชื่อเรื่อง: Differential effects of heat stress on fibre capillarisation in tenotomised soleus and plantaris muscles
ผู้แต่ง: Hirunsai M.
Srikuea R.
Keywords: myosin heavy chain
thrombospondin 1
vasculotropin receptor 2
Kdr protein, rat
thrombospondin 1
thrombospondin 1, rat
vascular endothelial growth factor A, rat
vasculotropin A
vasculotropin receptor 2
achilles tendon
angiogenesis
animal experiment
animal model
Article
capillary
clinical evaluation
comparative study
controlled study
glycolysis
heat stress
heat treatment
major histocompatibility complex
male
microcirculation
muscle atrophy
muscle fibril
muscle mass
nonhuman
plantaris muscle
protein expression
rat
soleus muscle
tenotomy
animal
capillary
heat shock response
metabolism
muscle atrophy
pathophysiology
physiology
skeletal muscle
surgery
tenotomy
Wistar rat
Achilles Tendon
Animals
Capillaries
Heat-Shock Response
Male
Muscle, Skeletal
Muscular Atrophy
Rats, Wistar
Tenotomy
Thrombospondin 1
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-2
วันที่เผยแพร่: 2018
บทคัดย่อ: Purpose: Capillary regression is commonly observed in response to disuse muscle atrophy. Heat stress is known to alleviate muscle atrophy, while effect of heat exposure on capillary adaptation following disuse atrophy is not defined. Here, we examined the effect of heat treatment on capillarisation and the associated signalling in slow-oxidative soleus and fast-glycolytic plantaris muscles following Achilles tendon ablation (tenotomy). Materials and methods: Male Wistar rats were assigned into control (CON), control with heat stress (CON + HEAT), tenotomy (TEN) and tenotomy with heat stress (TEN + HEAT) groups. Tenotomy was induced for 8 days in TEN and TEN + HEAT groups. Heat stress was maintained at 40.5–41.5 °C, 30 min for 7 days. Results: Tenotomy resulted in reduction of capillary-to-fibre ratio, decreased VEGFR-2 and increased TSP-1 in soleus muscle, whereas VEGF protein expression remained unaffected. Tenotomy had no effect on capillary distribution and angiogenic signalling in plantaris muscle. These results were concomitant with larger reduction of cross-sectional area (CSA) in MHC type I and II myofibres of soleus compared to plantaris muscles. Interestingly, heat stress increased VEGFR-2 and attenuated TSP-1 protein expression in tenotomised soleus, but not plantaris muscles. Additionally, CSA of both type I and type II myofibres was greater in tenotomised soleus than plantaris muscles after heat treatment. Conclusions: Heat stress mitigated effect of tenotomy-induced capillary regression in a fibre-type-specific response, in part, by shifting the balance between angiogenic and angiostatic regulators. These results suggest beneficial effect of heat treatment for maintaining microcirculation in disuse muscle atrophy. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13277
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025173317&doi=10.1080%2f02656736.2017.1350758&partnerID=40&md5=2ae5d21a5d34cbde8c74ea1960941767
ISSN: 2656736
Appears in Collections:Scopus 1983-2021

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