Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13231
ชื่อเรื่อง: Relationship between circadian clock genes and the neurotrophic factor genes in rat hippocampus
ผู้แต่ง: Pramong R.
Govitrapong P.
Phansuwan-Pujito P.
Keywords: brain derived neurotrophic factor
cryptochrome 1
messenger RNA
nerve growth factor
neurotrophic factor
nuclear receptor NR1D1
PER1 protein
transcription factor ARNTL
vasculotropin
adult
animal experiment
animal tissue
Article
bdnf gene
bmal1 gene
circadian clock gene
circadian rhythm
controlled study
cry1 gene
gene
gene expression
gene expression profiling
hippocampus
mRNA expression assay
neurotrophic factor gene
nonhuman
per1 gene
protein expression
rat
real time reverse transcription polymerase chain reaction
rev-erb alpha gene
RNA isolation
vegf gene
วันที่เผยแพร่: 2017
บทคัดย่อ: Background: The hippocampus, a key brain area for learning and memory, can express clock genes with circadian fashion. The neurotrophic factors are important for cognitive function in the hippocampus. The expression of circadian clock gene and neurotrophic factor in the hippocampus would be necessary to achieve and optimize daily memory performance. Objective: It is of interest to examine the daily expression patterns of neurotrophic factor genes and the link between these genes and clock genes in rat hippocampus. Material and Method: Daily expression profiles of four clock genes (Per1, Cry1, Bmal1, and Rev-erb alpha) and four neurotrophic factor genes (BDNF, NGF, NT-3, and VEGF) were analyzed in the rat hippocampus at 6 hours apart by real-time PCR. Results: The mRNAs of BDNF, NGF, and VEGF, but not NT-3 in hippocampus were expressed in circadian manner as well as those of clock genes. Correlation analysis revealed strong relationships between the expression of VEGF and Per1, VEGF and Rev-erb alpha, BDNF and Bmal1, and BDNF and Cry1. Conclusion: The present study suggests that VEGF and BDNF are clock-controlled genes relating to specific clock genes. Therefore, further investigation on the molecular mechanisms linking cognitive processes and circadian clock in hippocampus could be necessary to clarify their functions. © 2017 Medical Association of Thailand. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13231
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075002985&partnerID=40&md5=9127aff5fe845de5f511a7d363ae6d51
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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