Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13217
ชื่อเรื่อง: Steroid responsiveness in adults with primary immune thrombocytopenia: A single center study
ผู้แต่ง: Makruasi N.
Phukiat N.
Keywords: azathioprine
colchicine
cyclophosphamide
dexamethasone
immunoglobulin
prednisolone
steroid
adolescent
adult
aged
Article
blood cell count
clinical article
clinical outcome
controlled study
descriptive research
drug dose reduction
drug substitution
female
human
idiopathic thrombocytopenic purpura
immune response
male
platelet count
retrospective study
skin bleeding
thrombocytopenia
treatment outcome
very elderly
วันที่เผยแพร่: 2017
บทคัดย่อ: Background: Primary immune thrombocytopenia (ITP) is a common life-threatening condition of a benign hematologic disease. The standard treatment is corticosteroids. Dismal study to determine response between groups of steroids in Thailand. Assessing the steroid response of each form of steroid may improve the outcome of ITP. Objective: The objective is to determine the results of steroid administration in newly diagnosed or patients with relapsed primary ITP by comparing the response between prednisolone and dexamethasone. Material and Method: The study is a retrospective, descriptive study. We have reviewed medical records of thirty-nine primary ITP patients taken between the years of 2007 to 2014 at the HRH Princess Maha Chakri Sirindhorn Medical Center. Data collections were of the personal demographics, disease characteristics, treatments, and the outcomes of treatments. The statistical analyses include the percentages, mean scores, and standard deviation. The Chi-square and Fisher’s exact correlation were used to identify the categorical variables and to assess between the independent variables and outcomes. The ANOVA test confirmed the continuous variables. A p-value <0.05 was considered statistically significant. Results: Data from the 39 patients have shown that the median age was 40.6 years (15 to 85 years). The female gender was a predominant factor. Twenty-seven patients (69.2%) were newly diagnosed ITP. Most of the patients (84.62%) experienced a history of bleeding in which skin bleeding was the major type (60.6%). There were 15 (38.5%) and 24 (61.5%) patients treated with prednisolone and dexamethasone, respectively. The history of bleeding (p = 0.02) and low platelet counts prior to treatment (p=0.04) were seen predominantly in the dexamethasone group when compared to the prednisolone group. The accumulation of levels of steroids were found to be higher in the dexamethasone group during the first week (p = 0.00), but no differences were seen between 2 and 4 weeks of treatment (p = 0.20, 0.14, and 0.19). The initial response to therapy in the dexamethasone group was 77.2%, and 88.9% in prednisolone group. However, the 1 to 4 week treatment outcomes were not different between either of the groups. Gender, age (less than 18 years), diagnoses of being a new case or a relapsed case and the type of corticosteroid have shown no effects on the outcomes of the treatments. Conclusion: Dexamethasone and prednisolone provide equal clinical outcomes for the patients with ITP during the first month of the therapeutic regimens. © 2017 Medical Association of Thailand. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13217
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074982970&partnerID=40&md5=33208a5c6cb82fe66b016371ccd08f78
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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