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DC Field | Value | Language |
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dc.contributor.author | Yusook K. | |
dc.contributor.author | Weeranantanapan O. | |
dc.contributor.author | Hua Y. | |
dc.contributor.author | Kumkrai P. | |
dc.contributor.author | Chudapongse N. | |
dc.date.accessioned | 2021-04-05T03:22:21Z | - |
dc.date.available | 2021-04-05T03:22:21Z | - |
dc.date.issued | 2017 | |
dc.identifier.issn | 13403443 | |
dc.identifier.other | 2-s2.0-85007441143 | |
dc.identifier.uri | https://ir.swu.ac.th/jspui/handle/123456789/13114 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007441143&doi=10.1007%2fs11418-016-1065-2&partnerID=40&md5=d9e82075077be35f929b4a89fbf7e08c | |
dc.description.abstract | In this study, lupinifolin, a prenylated flavonoid, was isolated from Derris reticulata stem, identified by NMR spectra and confirmed with mass spectrometry. Lupinifolin was freshly prepared by solubilizing in 0.1 N NaOH and immediately diluted in Müller–Hinton broth for antibacterial testing. The data showed that Gram-positive bacteria were more susceptible to lupinifolin than Gram-negative bacteria. Of four strains of Gram-positive bacteria tested, Staphylococcus aureus was the most susceptible. Using the two-fold microdilution method, it was found that lupinifolin possessed antimicrobial activity against S. aureus with minimum inhibitory concentration and minimum bactericidal concentration of 8 and 16 µg/ml, respectively, which is less potent than ampicillin. However, from the time–effect relationship, it was shown that lupinifolin had faster onset than ampicillin. The faster onset of lupinifolin was confirmed by scanning electron microscopy. To investigate the mechanism of action of lupinifolin, transmission electron microscopy (TEM) was performed to observe the ultrastructure of S. aureus. The TEM images showed that lupinifolin ruptured the bacterial cell membrane and cell wall. Due to its fast onset, it is suggested that the action of lupinifolin is likely to be the direct disruption of the cell membrane. This hypothesis was substantiated by the data from flow cytometry using DiOC2 as an indicator. The result showed that the red/green ratio which indicated bacterial membrane integrity was significantly decreased, similar to the known protonophore carbonyl cyanide 3-chlorophenylhydrazone. It is concluded that lupinifolin inhibits the growth of S. aureus by damaging the bacterial cytoplasmic membrane. © 2016, The Japanese Society of Pharmacognosy and Springer Japan. | |
dc.subject | ampicillin | |
dc.subject | bactericide | |
dc.subject | Derris reticulata extract | |
dc.subject | lupinifolin | |
dc.subject | plant extract | |
dc.subject | unclassified drug | |
dc.subject | antiinfective agent | |
dc.subject | flavonoid | |
dc.subject | lupinifolin | |
dc.subject | antibiotic sensitivity | |
dc.subject | Article | |
dc.subject | bacterial cell wall | |
dc.subject | bactericidal activity | |
dc.subject | carbon nuclear magnetic resonance | |
dc.subject | controlled study | |
dc.subject | Derris | |
dc.subject | Derris reticulata | |
dc.subject | drug identification | |
dc.subject | drug isolation | |
dc.subject | drug mechanism | |
dc.subject | drug potency | |
dc.subject | drug screening | |
dc.subject | flow cytometry | |
dc.subject | mass spectrometry | |
dc.subject | minimum bactericidal concentration | |
dc.subject | minimum inhibitory concentration | |
dc.subject | nonhuman | |
dc.subject | plant stem | |
dc.subject | proton nuclear magnetic resonance | |
dc.subject | scanning electron microscopy | |
dc.subject | Staphylococcus aureus | |
dc.subject | transmission electron microscopy | |
dc.subject | ultrastructure | |
dc.subject | cell membrane | |
dc.subject | chemistry | |
dc.subject | pathogenicity | |
dc.subject | Staphylococcus aureus | |
dc.subject | Anti-Bacterial Agents | |
dc.subject | Cell Membrane | |
dc.subject | Derris | |
dc.subject | Flavonoids | |
dc.subject | Plant Stems | |
dc.subject | Staphylococcus aureus | |
dc.title | Lupinifolin from Derris reticulata possesses bactericidal activity on Staphylococcus aureus by disrupting bacterial cell membrane | |
dc.type | Article | |
dc.rights.holder | Scopus | |
dc.identifier.bibliograpycitation | Journal of Natural Medicines. Vol 71, No.2 (2017), p.357-366 | |
dc.identifier.doi | 10.1007/s11418-016-1065-2 | |
Appears in Collections: | Scopus 1983-2021 |
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