Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13080
ชื่อเรื่อง: Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study
ผู้แต่ง: Tangkiatkumjai M.
Walker D.-M.
Praditpornsilpa K.
Boardman H.
Keywords: acetylsalicylic acid
allopurinol
angiotensin receptor antagonist
antidiabetic agent
antihypertensive agent
antilipemic agent
bicarbonate
cyclooxygenase 2 inhibitor
dipeptidyl carboxypeptidase inhibitor
erythropoietin
folic acid
glycosylated hemoglobin
iron derivative
loop diuretic agent
low density lipoprotein cholesterol
nonsteroid antiinflammatory agent
phosphate binding agent
polystyrenesulfonate calcium
polystyrenesulfonate sodium
thiamine
antidiabetic agent
antihypertensive agent
antilipemic agent
biological marker
creatinine
glycosylated hemoglobin
hemoglobin A1c protein, human
low density lipoprotein cholesterol
adult
aged
anemia
Article
blood pressure measurement
blood pressure regulation
chronic kidney failure
clinical outcome
cohort analysis
creatinine blood level
disease course
estimated glomerular filtration rate
female
human
hyperphosphatemia
major clinical study
male
medication compliance
prospective study
renal replacement therapy
Thailand
blood
blood pressure
chi square distribution
chronic kidney failure
disease exacerbation
disorders of carbohydrate metabolism
drug effects
dyslipidemia
glomerulus filtration rate
hypertension
kidney
metabolism
middle aged
multivariate analysis
odds ratio
pathophysiology
risk factor
statistical model
time factor
treatment outcome
very elderly
Aged
Aged, 80 and over
Antihypertensive Agents
Biomarkers
Blood Pressure
Chi-Square Distribution
Cholesterol, LDL
Creatinine
Disease Progression
Dyslipidemias
Female
Glomerular Filtration Rate
Glucose Metabolism Disorders
Glycated Hemoglobin A
Humans
Hypertension
Hypoglycemic Agents
Hypolipidemic Agents
Kidney
Logistic Models
Male
Medication Adherence
Middle Aged
Multivariate Analysis
Odds Ratio
Prospective Studies
Renal Insufficiency, Chronic
Risk Factors
Thailand
Time Factors
Treatment Outcome
วันที่เผยแพร่: 2017
บทคัดย่อ: Background: There is limited evidence of medication adherence related to progression of chronic kidney disease (CKD) worldwide. The aim of this study was to determine associations between medication adherence and the progression of CKD in outpatients with CKD. Methods: This cohort study recruited 339 Thai patients with stages 3–5 CKD. Patients with a glomerular disease or receiving renal replacement therapy before recruitment were excluded. 295 were followed up regarding their serum creatinine, blood pressure, glycated hemoglobin, and low-density lipoprotein cholesterol over 12 months. Medication adherence was measured at baseline using the Thai version of the 8-Item Morisky Medication Adherence Scale®. The primary outcome was the progression of CKD. The progression of CKD was defined as either a decline in estimated glomerular filtration rate of at least 3 ml/min/1.73 m2/year or initiation of renal replacement therapy. Univariate and multivariate analyses were performed using Chi-squared tests and multiple logistic regressions. Results: Twenty-one percent had poor adherence. Younger patients were more likely to have poor adherence (adjusted OR 2.81, 95 % CI 1.45–5.43). Anti-hypertensive agents were the most frequently reported as not being taken (52 %). Patients with poor adherence were associated with the progression of CKD (adjusted OR 1.96, 95 % CI 1.02–3.76). Those with poor adherence were less likely to control their blood pressure, than moderate-to-high adherence group (p < 0.01). Conclusion: The findings suggest that CKD patients with poor medication adherence are more likely to have progression of CKD. Health care providers should acknowledge these findings and provide effective strategies to deal with this issue. © 2016, Japanese Society of Nephrology.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13080
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979300188&doi=10.1007%2fs10157-016-1312-6&partnerID=40&md5=a1c8aa3b9f562bb691e4bc4141380607
ISSN: 13421751
Appears in Collections:Scopus 1983-2021

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