Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13068
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dc.contributor.authorJiamvoraphong N.-
dc.contributor.authorJantaratnotai N.-
dc.contributor.authorSanvarinda P.-
dc.contributor.authorTuchinda P.-
dc.contributor.authorPiyachaturawat P.-
dc.contributor.authorThampithak A.-
dc.contributor.authorSanvarinda P.-
dc.date.accessioned2021-04-05T03:22:12Z-
dc.date.available2021-04-05T03:22:12Z-
dc.date.issued2017-
dc.identifier.issn223573-
dc.identifier.other2-s2.0-85017333796-
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13068-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017333796&doi=10.1111%2fjphp.12723&partnerID=40&md5=611db4b0a0928dd036e66bd44b0321f8-
dc.description.abstractObjective: We investigated the molecular mechanisms underlying the effect of (3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol, also known as compound 092, isolated from Curcuma comosa Roxb on the production of pro-inflammatory mediators and oxidative stress in lipopolysaccharide (LPS)-activated highly aggressive proliferating immortalized (HAPI) microglial cell lines. Method: Nitric oxide (NO) production was determined using the Griess reaction, and reverse transcription polymerase chain reaction was used to measure the expression of inducible nitric oxide synthase (iNOS) mRNA. Western blotting was used to determine the levels of pro-inflammatory mediators and their related upstream proteins. Key finding: Compound 092 suppressed NO production and iNOS expression in LPS-stimulated HAPI cells. These effects originated from the ability of compound 092 to attenuate the activation of nuclear factor (NF)-κB as determined by the reduction in p-NF-κB and p-IκB kinase (IKK) protein levels. Compound 092 also significantly lowered LPS-activated intracellular reactive oxygen species production and p38 mitogen-activated protein kinase (MAPK) activation. Conclusion: Compound 092 suppresses microglial activation through attenuation of p38 MAPK and NF-κB activation. Compound 092 thus holds the potential to treat neurodegenerative disorders associated with neuroinflammation and oxidative stress. © 2017 Royal Pharmaceutical Society-
dc.subjectI kappa B kinase-
dc.subjectimmunoglobulin enhancer binding protein-
dc.subjectlipopolysaccharide-
dc.subjectmitogen activated protein kinase p38-
dc.subjectnitric oxide synthase-
dc.subjectplant extract-
dc.subjectreactive oxygen metabolite-
dc.subjectunclassified drug-
dc.subjectautacoid-
dc.subjectheptane derivative-
dc.subjectI kappa B-
dc.subjectimmunoglobulin enhancer binding protein-
dc.subjectinducible nitric oxide synthase-
dc.subjectlipopolysaccharide-
dc.subjectmitogen activated protein kinase p38-
dc.subjectnitric oxide-
dc.subjectreactive oxygen metabolite-
dc.subjectArticle-
dc.subjectcell proliferation-
dc.subjectcontrolled study-
dc.subjectCurcuma-
dc.subjectCurcuma comosa-
dc.subjectdegenerative disease-
dc.subjectdisease association-
dc.subjectdrug structure-
dc.subjectmicroglia-
dc.subjectnervous system inflammation-
dc.subjectnonhuman-
dc.subjectoxidative stress-
dc.subjectprotein expression-
dc.subjectreverse transcription polymerase chain reaction-
dc.subjectWestern blotting-
dc.subjectanimal-
dc.subjectcell line-
dc.subjectchemistry-
dc.subjectdrug effects-
dc.subjectgene expression regulation-
dc.subjectisolation and purification-
dc.subjectmetabolism-
dc.subjectmicroglia-
dc.subjectrat-
dc.subjectAnimals-
dc.subjectBlotting, Western-
dc.subjectCell Line-
dc.subjectCurcuma-
dc.subjectDiarylheptanoids-
dc.subjectGene Expression Regulation-
dc.subjectI-kappa B Proteins-
dc.subjectInflammation Mediators-
dc.subjectLipopolysaccharides-
dc.subjectMicroglia-
dc.subjectNF-kappa B-
dc.subjectNitric Oxide-
dc.subjectNitric Oxide Synthase Type II-
dc.subjectOxidative Stress-
dc.subjectp38 Mitogen-Activated Protein Kinases-
dc.subjectRats-
dc.subjectReactive Oxygen Species-
dc.titleConcurrent suppression of NF-κB, p38 MAPK and reactive oxygen species formation underlies the effect of a novel compound isolated from Curcuma comosa Roxb. in LPS-activated microglia-
dc.typeArticle-
dc.rights.holderScopus-
dc.identifier.bibliograpycitationJournal of Pharmacy and Pharmacology. Vol 69, No.7 (2017), p.917-924-
dc.identifier.doi10.1111/jphp.12723-
Appears in Collections:Scopus 1983-2021

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