Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13020
ชื่อเรื่อง: CXCR4 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition
ผู้แต่ง: Chittasupho C.
Anuchapreeda S.
Sarisuta N.
Keywords: chemokine receptor
chemokine receptor CXCR4
dendrimer
doxorubicin
LFC131 peptide
ligand
peptide
polyamidoamine
unclassified drug
antineoplastic agent
chemokine receptor CXCR4
CXCR4 protein, human
dendrimer
doxorubicin
PAMAM Starburst
stromal cell derived factor 1
Article
binding affinity
breast cancer cell line
BT-549-Luc cell line
cell migration
cell surface
cell viability assay
chemotaxis assay
competitive binding assay
conjugation
controlled study
cytotoxicity
drug delivery system
drug efficacy
drug receptor binding
drug release
drug uptake
human
human cell
IC50
in vitro study
incubation time
migration inhibition
nanoencapsulation
physical chemistry
protein expression
T47D cell line
breast tumor
cell motion
drug delivery system
drug effects
female
metabolism
migration inhibition
procedures
signal transduction
tumor cell line
Antineoplastic Agents
Breast Neoplasms
Cell Line, Tumor
Cell Migration Inhibition
Cell Movement
Chemokine CXCL12
Dendrimers
Doxorubicin
Drug Delivery Systems
Female
Humans
Receptors, CXCR4
Signal Transduction
วันที่เผยแพร่: 2017
บทคัดย่อ: CXCR4 and its ligand CXCL12 play a critical role in the metastasis of various types of cancer including breast cancer. Breast tumors preferentially metastasize to the lung, bones and distant lymph nodes, secreting high levels of CXCL12. We hypothesized that targeted inhibition of CXCR4 in breast cancer cells should suppress CXCR4-positive tumor cells toward secondary metastatic sites. In the present study, the efficacy of CXCR4 targeted dendrimers carrying DOX (LFC131-DOX-D4) on cellular binding, cytotoxicity, and migration of BT-549-Luc and T47D breast cancer cells was investigated. PAMAM dendrimers encapsulating DOX was surface functionalized with LFC131 peptide which recognized CXCR4 expressed on the surface of breast cancer cells. The LFC131-DOX-D4 bound to breast cancer cells resulting in significantly enhanced in vitro cellular toxicity as compared with non-targeted dendrimers. The LFC131-D4 exhibited remarkable reduced migration of BT-549-Luc breast cancer cells toward chemoattractant. This report demonstrated the potential utility of LFC131-dendrimer conjugates for breast cancer therapy and metastasis. © 2017 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13020
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85023190732&doi=10.1016%2fj.ejpb.2017.07.003&partnerID=40&md5=62b5e465c56012aa6ea5e9b32623322e
ISSN: 9396411
Appears in Collections:Scopus 1983-2021

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