Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12983
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dc.contributor.authorJomoui W.
dc.contributor.authorFucharoen G.
dc.contributor.authorSanchaisuriya K.
dc.contributor.authorNguyen N.T.
dc.contributor.authorNguyen H.V.
dc.contributor.authorFucharoen S.
dc.date.accessioned2021-04-05T03:21:57Z-
dc.date.available2021-04-05T03:21:57Z-
dc.date.issued2017
dc.identifier.issn3014460
dc.identifier.other2-s2.0-85031780244
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12983-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031780244&doi=10.1080%2f03014460.2017.1388844&partnerID=40&md5=c9477ace403c82eb9435c294d4c7594f
dc.description.abstractHaemoglobin (Hb) E is the most common Hb variant in Asia where its gene frequency approaches 0.3 in some areas. We studied genetic background of Hb E genes among Southeast Asian populations. This study examined β-globin gene haplotypes linked to haemoglobin E (Hb E) in diverse groups of Southeast Asian populations. The study was conducted on southern Thai (22 alleles), Cambodian (84 alleles), Laotian (120 alleles), Vietnamese (87 alleles) and Burmese (one allele) subjects. Results were compared with those of previous studies in northeast Thailand, the Yunnan of China, West India and Europe. Ten different haplotypes were observed. The four most common haplotypes were haplotypes 1 (– +–+ + + –) and 2 (+–––– + –) on chromosomes with framework 2 and haplotypes 6 (– +–+ +–+) and 7 (+–––––+) on chromosomes with framework 3 variety. Phylogenetic analysis indicated that haplotype 1 is a relatively recent haplotype found in all populations, whereas haplotype 6 is found predominately in Cambodians. The results indicate that at least two genetic origins of Hb E are responsible for the high prevalence and spread of Hb E among Southeast Asian populations. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
dc.subjectchromosome
dc.subjectgene expression
dc.subjectgenetic analysis
dc.subjecthemoglobin
dc.subjectmolecular analysis
dc.subjectphylogenetics
dc.subjectCambodia
dc.subjectChina
dc.subjectEurope
dc.subjectIndia
dc.subjectSouth Asia
dc.subjectThailand
dc.subjectYunnan
dc.subjectLaotia
dc.subjecthemoglobin E
dc.subjectallele
dc.subjectgenetics
dc.subjecthaplotype
dc.subjecthuman
dc.subjectphylogeny
dc.subjectSoutheast Asia
dc.subjectAlleles
dc.subjectAsia, Southeastern
dc.subjectHaplotypes
dc.subjectHemoglobin E
dc.subjectHumans
dc.subjectPhylogeny
dc.titleMolecular analysis of haemoglobin E in Southeast Asian populations
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAnnals of Human Biology. Vol 44, No.8 (2017), p.747-750
dc.identifier.doi10.1080/03014460.2017.1388844
Appears in Collections:Scopus 1983-2021

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