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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12962
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dc.contributor.authorCkumdee J.
dc.contributor.authorSantiwatanakul S.
dc.contributor.authorKaewphinit T.
dc.date.accessioned2021-04-05T03:21:54Z-
dc.date.available2021-04-05T03:21:54Z-
dc.date.issued2017
dc.identifier.issn19300395
dc.identifier.other2-s2.0-85044288537
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12962-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044288537&doi=10.1109%2fICSENS.2017.8234337&partnerID=40&md5=d7a8e20b92fc8ba59403e3a5ac39d6f3
dc.description.abstractNovel loop mediated isothermal amplification (LAMP) can also detect one based point mutation drug resistance in Mycobacterium tuberculosis (MTB), by designing inner primers of 5' end specific with the mutant. The reaction was optimized by in-house turbidity biosensor at 61°C, 60 min. It showed the potential to provide a rapid and sensitive method for detecting isoniazid resistant at katG gene position 315 (G→C). The 30 clinical samples were also tested and showed 100% specificity and sensitivity comparing with Genotype® MDR-TB Plus. It could be convenient for detection of MDR-TB in field samples as well. © 2017 IEEE.
dc.subjectBiosensors
dc.subjectDrug therapy
dc.subjectGenes
dc.subjectHydrazine
dc.subjectIsotherms
dc.subjectPharmacodynamics
dc.subjectClinical samples
dc.subjectDrug resistance
dc.subjectIn-field
dc.subjectLoop mediated isothermal amplifications
dc.subjectMulti-drug resistant tuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectPoint mutations
dc.subjectSensitive method
dc.subjectTurbidity
dc.titleDevelopment of a rapid and sensitive DNA turbidity biosensor test for diagnosis of katG gene in isoniazid resistant Mycobacterium tuberculosis
dc.typeConference Paper
dc.rights.holderScopus
dc.identifier.bibliograpycitationProceedings of IEEE Sensors. Vol 2017-December, (2017), p.1-3
dc.identifier.doi10.1109/ICSENS.2017.8234337
Appears in Collections:Scopus 1983-2021

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