Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12942
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dc.contributor.authorAlp Ikizler T.
dc.contributor.authorRobinson-Cohen C.
dc.contributor.authorEllis C.
dc.contributor.authorHeadley S.A.E.
dc.contributor.authorTuttle K.
dc.contributor.authorWood R.J.
dc.contributor.authorEvans E.E.
dc.contributor.authorMilch C.M.
dc.contributor.authorMoody K.A.
dc.contributor.authorGermain M.
dc.contributor.authorLimkunakul C.
dc.contributor.authorBian A.
dc.contributor.authorStewart T.G.
dc.contributor.authorHimmelfarb J.
dc.date.accessioned2021-04-05T03:21:52Z-
dc.date.available2021-04-05T03:21:52Z-
dc.date.issued2018
dc.identifier.issn10466673
dc.identifier.other2-s2.0-85040117215
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12942-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040117215&doi=10.1681%2fASN.2017010020&partnerID=40&md5=0650c3afb503d6b98a4c69548f88e7ea
dc.description.abstractCKD is steadily increasing along with obesity worldwide. Furthermore, obesity is a proinflammatory risk factor for progression of CKD and cardiovascular disease. We tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and can improve the proinflammatory metabolic milieu in patients with moderate to severe CKD through a pilot, randomized, 232 factorial design trial. Of 122 participants consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or usual care. Of those randomized, 42% were women, 25% were diabetic, and 91% were hypertensive; 104 started intervention, and 92 completed the 4-month study. Primary outcomes were a change from baseline in absolute fat mass, body weight, plasma F2-isoprostane concentrations, and peak oxygen uptake (VO2 peak). Compared with usual care, the combined intervention led to statistically significant decreases in body weight and body fat percentage. Caloric restriction alone also led to significant decreases in these measures, but aerobic exercise alone did not. The combined intervention and each independent intervention also led to significant decreases in F2-isoprostane and IL-6 concentrations. No intervention produced significant changes in VO2 peak, kidney function, or urine albumin-to-creatinine ratio. In conclusion, 4-month dietary calorie restriction and aerobic exercise had significant, albeit clinically modest, benefits on body weight, fat mass, and markers of oxidative stress and inflammatory response in patients with moderate to severe CKD. These results suggest healthy lifestyle interventions as a nonpharmacologic strategy to improve markers of metabolic health in these patients. Copyright © 2018 by the American Society of Nephrology.
dc.subjectalbumin
dc.subjectcreatinine
dc.subjectinterleukin 6
dc.subjectisoprostane derivative
dc.subjectoxygen
dc.subjectcreatinine
dc.subjectIL6 protein, human
dc.subjectinterleukin 6
dc.subjectisoprostane derivative
dc.subjectadult
dc.subjectaerobic exercise
dc.subjectaged
dc.subjectArticle
dc.subjectblood level
dc.subjectbody weight
dc.subjectcaloric restriction
dc.subjectchronic kidney failure
dc.subjectclinical outcome
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectfat mass
dc.subjectfemale
dc.subjecthuman
dc.subjecthypertension
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoxygen consumption
dc.subjectpilot study
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectalbuminuria
dc.subjectblood
dc.subjectchronic kidney failure
dc.subjectexercise
dc.subjectglomerulus filtration rate
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjecturine
dc.subjectAdiposity
dc.subjectAged
dc.subjectAlbuminuria
dc.subjectBody Weight
dc.subjectCaloric Restriction
dc.subjectCreatinine
dc.subjectExercise
dc.subjectF2-Isoprostanes
dc.subjectFemale
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectInterleukin-6
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOxidative Stress
dc.subjectOxygen Consumption
dc.subjectPilot Projects
dc.subjectRenal Insufficiency, Chronic
dc.titleMetabolic effects of diet and exercise in patients with moderate to severe CKD: A randomized clinical trial
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of the American Society of Nephrology. Vol 29, No.1 (2018), p.250-259
dc.identifier.doi10.1681/ASN.2017010020
Appears in Collections:Scopus 1983-2021

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