Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12754
ชื่อเรื่อง: Clinical features and antibiotic susceptibility of salmonella gastroenteritis in children: A ten-year review
ผู้แต่ง: Takkinsatian P.
Silpskulsuk C.
Prommalikit O.
Keywords: ampicillin
cephalosporin
cotrimoxazole
norfloxacin
quinoline derived antiinfective agent
adolescent
antibiotic sensitivity
Article
bacteremia
bacterial arthritis
bloody mucus
child
child hospitalization
clinical feature
diarrhea
female
fever
gastroenteritis
human
immunocompromised patient
infant
intensive care unit
length of stay
major clinical study
male
meningitis
newborn
retrospective study
Salmonella
serotype
Verner Morrison syndrome
vomiting
วันที่เผยแพร่: 2020
บทคัดย่อ: Introduction: Salmonella is a common organism, causing intestinal and extraintestinal infections among Thai children, especially infants, and leading to overwhelming antibiotic use. Materials and Methods: In this retrospective review, data collected during 2006-2015 from the medical charts of patients with evidence of infection, caused by any Salmonella serogroup or clinical form, were examined. We aimed to assess the clinical manifestations, antibiotic susceptibility, and antibiotic use in children with Salmonella gastroenteritis over the ten years’ period. Results: A total of 419 patients had non-typhoidal Salmonella infection. Four-hundred (95.5%) patients were diagnosed with acute gastroenteritis, which was common in children aged <12 months (72.3%). The clinical features of patients with gastroenteritis included fever (74.5%), diarrhoea with bloody mucus (60.5%), watery diarrhoea (39.5%), and vomiting (19.8%). Serogroup B was most commonly detected in the stool specimens. The susceptibility of non-typhoidal Salmonella to ampicillin, norfloxacin, and co-trimoxazole was 36.3%, 98.0%, and 80.5%, respectively. Serogroup B was the most resistant strain, which was sensitive to ampicillin in only 21.6% of specimens, while it showed high susceptibility to norfloxacin and co-trimoxazole (98.1 and 84.0%, respectively). Third-generation cephalosporin and fluoroquinolone were most commonly prescribed. Conclusions: Acute gastroenteritis is the most common form of Salmonella infection. Gastroenteritis caused by serogroup B is still the most common infection, which mostly occurs among infants under one year of age. The majority of stool specimens were still susceptible to antimicrobial agents, especially fluoroquinolone and cotrimoxazole; however, there was an overuse of antibiotics without proper indications. © 2020, Malaysian Medical Association. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12754
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096398102&partnerID=40&md5=0fe32a39e4019a9888fc137a33a1ae7b
ISSN: 3005283
Appears in Collections:Scopus 1983-2021

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