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dc.contributor.authorGritsch L.
dc.contributor.authorConoscenti G.
dc.contributor.authorLa Carrubba V.
dc.contributor.authorNooeaid P.
dc.contributor.authorBoccaccini A.R.
dc.date.accessioned2021-04-05T03:04:56Z-
dc.date.available2021-04-05T03:04:56Z-
dc.date.issued2019
dc.identifier.issn9284931
dc.identifier.other2-s2.0-85053931733
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12678-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053931733&doi=10.1016%2fj.msec.2018.09.038&partnerID=40&md5=c8553b8bc63b994122f7cdccb9d583c1
dc.description.abstractIn a large number of medical devices, a key feature of a biomaterial is the ability to successfully bond to living tissues by means of engineered mechanisms such as the enhancement of biomineralization on a bone tissue engineering scaffold or the mimicking of the natural structure of the extracellular matrix (ECM). This ability is commonly referred to as “bioactivity”. Materials sciences started to grow interest in it since the development of bioactive glasses by Larry Hench five decades ago. As the main goal in applications of biomedical devices and tissue scaffolds is to obtain a seamless tissue-material interface, achieving optimal bioactivity is essential for the success of most biomaterial-based tissue replacement and regenerative approaches. Polymers derived from lactic acid are largely adopted in the biomedical field, they are versatile, FDA approved and relatively cost-effective. However, as for many other widespread biomedical polymers, they are hydrophobic and lack the intrinsic ability of positively interacting with surrounding tissues. In the last decades scientists have studied many solutions to exploit the positive characteristics of polylactide-based materials overcoming this bottleneck at the same time. The efforts of this research fruitfully produced many effective tissue engineering technologies based on PLA and related biopolymers. This review aims to give an overview on the latest and most promising strategies to improve the bioactivity of lactic acid-based materials, especially focusing on biomolecule-free bulk approaches such as blending, copolymerization or composite fabrication. Avenues for future research to tackle current needs in the field are identified and discussed. © 2018 Elsevier B.V.
dc.subjectBioactive glass
dc.subjectBioactivity
dc.subjectBiomedical equipment
dc.subjectBiomineralization
dc.subjectBiomolecules
dc.subjectBiopolymers
dc.subjectBlending
dc.subjectComposite materials
dc.subjectCost effectiveness
dc.subjectFunctional polymers
dc.subjectGrowth (materials)
dc.subjectHistology
dc.subjectInterfaces (materials)
dc.subjectLactic acid
dc.subjectPolyesters
dc.subjectScaffolds
dc.subjectScaffolds (biology)
dc.subjectStructure (composition)
dc.subjectTissue engineering
dc.subjectBiological molecule
dc.subjectBiomedical devices
dc.subjectBiomedical polymers
dc.subjectBone tissue engineering
dc.subjectComposite fabrication
dc.subjectExtracellular matrices
dc.subjectMaterial interfaces
dc.subjectPoly lactic acid
dc.subjectTissue
dc.subjectpolyester
dc.subjectpolylactide
dc.subjectsignal peptide
dc.subjectanimal
dc.subjectchemistry
dc.subjecthuman
dc.subjectmaterials science
dc.subjectsynthesis
dc.subjecttissue engineering
dc.subjecttissue scaffold
dc.subjectAnimals
dc.subjectHumans
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectMaterials Science
dc.subjectPolyesters
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.titlePolylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules
dc.typeReview
dc.rights.holderScopus
dc.identifier.bibliograpycitationMaterials Science and Engineering C. Vol 94, (2019), p.1083-1101
dc.identifier.doi10.1016/j.msec.2018.09.038
Appears in Collections:Scopus 1983-2021

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