Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12656
ชื่อเรื่อง: Pancreatic neuroendocrine tumor, lymphoma, and squamous cell carcinoma of hypopharynx; A case report of three primary cancers in one patient
ผู้แต่ง: Tangsirapat V.
Wongta K.
Chakrapan Na Ayudhya K.
Chakrapan Na Ayudhya V.
Sookpotarom P.
Keywords: CD20 antigen
Ki 67 antigen
methotrexate
neuron specific enolase
receptor type tyrosine protein phosphatase C
synaptophysin
adult
antigen expression
Article
axillary lymph node
cancer adjuvant therapy
cancer diagnosis
cancer regression
cancer staging
case report
chemoradiotherapy
clinical article
computer assisted tomography
diabetes mellitus
diffuse large B cell lymphoma
distal pancreatectomy
human
hypertension
hypopharynx squamous cell carcinoma
immunohistochemistry
incidental finding
inguinal region
lymphadenopathy
male
medical history
middle aged
odynophagia
orchiectomy
pancreas islet cell tumor
priority journal
radiation response
smoking
splenectomy
surgical margin
testis tumor
วันที่เผยแพร่: 2019
บทคัดย่อ: Background: Pancreatic neuroendocrine tumors (PNETs) are rarely found and the majority of PNETs are nonfunctioning. At present, a patient with pancreatic neuroendocrine tumor (PNET), lymphoma, and squamous cell carcinoma (SCC) occurring simultaneously has not been reported. We presented all these three primary cancers in a same patient. Case presentation: A 51-year-old male presented with a right testicular mass for four months. He underwent right orchidectomy, and the patient was diagnosed malignant diffuse large B-cell lymphoma. Consequently, CHOP regimen and intrathecal methotrexate were given as treatment. During the metastasis work up, a hypodense lesion at the tail of pancreas was found. Distal pancreatectomy and splenectomy were completed, and the pathological report revealed PNET. Eighteen months later, the patient developed a symptom of odynophagia, direct laryngoscopy was performed and a mass at the left arytenoid was found. The biopsy was done and confirmed the diagnosis of SCC. The patient went through concurrent chemo-radiation with a complete response. Currently the patient remains in a complete remission of all three cancers. Discussion: As the patient had non-functioning PNET and was symptom-free, the diagnosis would have not been discovered without the metastasis workup of lymphoma. Although non-functioning PNET less than 2 cm can be safely observed, the tumor was 4.3 × 1.3 cm and adenocarcinoma was suspected, so the patient underwent the surgery. Conclusion: Although many cases with multiple primary cancers have been published, a case of patient with PNET, lymphoma, and SCC occurring as primary cancers has not been yet reported. © 2019 The Author(s)
URI: https://ir.swu.ac.th/jspui/handle/123456789/12656
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074370143&doi=10.1016%2fj.ijscr.2019.10.073&partnerID=40&md5=5b9a16290d25b029551b8842ea027afa
ISSN: 22102612
Appears in Collections:Scopus 1983-2021

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