Please use this identifier to cite or link to this item:
https://ir.swu.ac.th/jspui/handle/123456789/12640
Title: | Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus |
Authors: | Patjana T. Jantaharn P. Katrun P. Mongkolthanaruk W. Suwannasai N. Senawong T. Tontapha S. Amornkitbumrung V. McCloskey S. |
Issue Date: | 2019 |
Abstract: | The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. |
URI: | https://ir.swu.ac.th/jspui/handle/123456789/12640 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071024282&doi=10.1080%2f14786419.2019.1652292&partnerID=40&md5=38a2f447c8d906b70394b5545a002d26 |
ISSN: | 14786419 |
Appears in Collections: | Scopus 1983-2021 |
Files in This Item:
There are no files associated with this item.
Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.