Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12640
Title: Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
Authors: Patjana T.
Jantaharn P.
Katrun P.
Mongkolthanaruk W.
Suwannasai N.
Senawong T.
Tontapha S.
Amornkitbumrung V.
McCloskey S.
Issue Date: 2019
Abstract: The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12640
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071024282&doi=10.1080%2f14786419.2019.1652292&partnerID=40&md5=38a2f447c8d906b70394b5545a002d26
ISSN: 14786419
Appears in Collections:Scopus 1983-2021

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