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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12615
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dc.contributor.authorPaiboonvong T.
dc.contributor.authorNosoongnoen W.
dc.contributor.authorSathirakul K.
dc.contributor.authorTangsujaritvijit V.
dc.contributor.authorKaemapairoj J.
dc.contributor.authorTragulpiankit P.
dc.contributor.authorMontakantikul P.
dc.date.accessioned2021-04-05T03:04:26Z-
dc.date.available2021-04-05T03:04:26Z-
dc.date.issued2019
dc.identifier.issn664804
dc.identifier.other2-s2.0-85072588748
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/12615-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072588748&doi=10.1128%2fAAC.00800-19&partnerID=40&md5=62351e29caba94e1451796b151040b0e
dc.description.abstractSitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) Copyright © 2019 American Society for Microbiology. All Rights Reserved.
dc.subjectsitafloxacin
dc.subjectantiinfective agent
dc.subjectquinolone derivative
dc.subjectsitafloxacin
dc.subjectadult
dc.subjectaged
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectcritically ill patient
dc.subjectdrug blood level
dc.subjectdrug penetration
dc.subjectelimination half-life
dc.subjectelimination rate constant
dc.subjectepithelial lining fluid
dc.subjectfemale
dc.subjecthuman
dc.subjectliquid
dc.subjectlung lavage fluid
dc.subjectmale
dc.subjectoral clearance
dc.subjectpharmacokinetic parameters
dc.subjectpneumonia
dc.subjectpriority journal
dc.subjectsingle drug dose
dc.subjectThai (citizen)
dc.subjecttime to maximum plasma concentration
dc.subjectvolume of distribution
dc.subjectbronchoalveolar lavage fluid
dc.subjectcritical illness
dc.subjectdrug effect
dc.subjectlung
dc.subjectlung alveolus macrophage
dc.subjectlung lavage
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectpneumonia
dc.subjectprocedures
dc.subjectrespiratory mucosa
dc.subjectThailand
dc.subjectAdult
dc.subjectAged
dc.subjectAnti-Bacterial Agents
dc.subjectBronchoalveolar Lavage
dc.subjectBronchoalveolar Lavage Fluid
dc.subjectCritical Illness
dc.subjectFemale
dc.subjectFluoroquinolones
dc.subjectHumans
dc.subjectLung
dc.subjectMacrophages, Alveolar
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPneumonia
dc.subjectRespiratory Mucosa
dc.subjectThailand
dc.titlePharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAntimicrobial Agents and Chemotherapy. Vol 63, No.10 (2019)
dc.identifier.doi10.1128/AAC.00800-19
Appears in Collections:Scopus 1983-2021

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