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https://ir.swu.ac.th/jspui/handle/123456789/12615| Title: | Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia |
| Authors: | Paiboonvong T. Nosoongnoen W. Sathirakul K. Tangsujaritvijit V. Kaemapairoj J. Tragulpiankit P. Montakantikul P. |
| Keywords: | sitafloxacin antiinfective agent quinolone derivative sitafloxacin adult aged area under the curve Article blood sampling clinical article critically ill patient drug blood level drug penetration elimination half-life elimination rate constant epithelial lining fluid female human liquid lung lavage fluid male oral clearance pharmacokinetic parameters pneumonia priority journal single drug dose Thai (citizen) time to maximum plasma concentration volume of distribution bronchoalveolar lavage fluid critical illness drug effect lung lung alveolus macrophage lung lavage metabolism microbiology middle aged pneumonia procedures respiratory mucosa Thailand Adult Aged Anti-Bacterial Agents Bronchoalveolar Lavage Bronchoalveolar Lavage Fluid Critical Illness Female Fluoroquinolones Humans Lung Macrophages, Alveolar Male Middle Aged Pneumonia Respiratory Mucosa Thailand |
| Issue Date: | 2019 |
| Abstract: | Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) Copyright © 2019 American Society for Microbiology. All Rights Reserved. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/12615 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072588748&doi=10.1128%2fAAC.00800-19&partnerID=40&md5=62351e29caba94e1451796b151040b0e |
| ISSN: | 664804 |
| Appears in Collections: | Scopus 1983-2021 |
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