Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12452
ชื่อเรื่อง: Bacterial colonization and antimicrobial resistance genes in neonatal enteral feeding tubes
ผู้แต่ง: Taft D.H.
Salinero L.K.
Vongbhavit K.
Kalanetra K.M.
Masarweh C.
Yu A.
Underwood M.A.
Mills D.A.
Keywords: antimicrobial activity
bacterial disease
bacterium
colonization
gene
genetic analysis
species diversity
Bacteria (microorganisms)
RNA 16S
antibiotic resistance
artificial milk
bacterial genome
bacterium
breast milk
classification
devices
enteric feeding
feces
genetics
human
isolation and purification
microbiology
microflora
neonatal intensive care unit
newborn
Bacteria
Drug Resistance, Bacterial
Enteral Nutrition
Feces
Genome, Bacterial
Humans
Infant Formula
Infant, Newborn
Intensive Care Units, Neonatal
Microbiota
Milk, Human
RNA, Ribosomal, 16S
วันที่เผยแพร่: 2019
บทคัดย่อ: Enteral feeding is a key component of care in neonatal intensive care units (NICUs); however, feeding tubes harbor microbes. These microbes have the potential to cause disease, yet their source remains controversial and clinical recommendations to reduce feeding tube colonization are lacking. This study aims to improve our understanding of the bacteria in neonatal feeding tubes and to evaluate factors that may affect these bacteria. 16S rRNA gene sequencing was used to characterize the bacteria present in pharyngeal, esophageal, and gastric portions of feeding tubes, residual fluid of the tubes, and infant stool using samples from 47 infants. Similar distributions of taxa were observed in all samples, although beta diversity differed by sample type. Feeding tube samples had lower alpha diversity than stool samples, and alpha diversity increased with gestational age, day of life, and tube dwell time. In a subset of samples from 6 infants analyzed by whole metagenome sequencing, there was greater overlap in transferable antimicrobial resistance genes between tube and fecal samples in breast milk fed infants than in formula fed infants. These findings develop our understanding of neonatal feeding tube colonization, laying a foundation for research into methods for minimizing NICU patients' exposure to antimicrobial resistant microbes. © 2019 FEMS 2019.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12452
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064284508&doi=10.1093%2ffemsec%2ffiz039&partnerID=40&md5=0d5f3e63394ba079ec3e4d99a63a1eff
ISSN: 1686496
Appears in Collections:Scopus 1983-2021

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