Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12446
ชื่อเรื่อง: Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells
ผู้แต่ง: Boondireke S.
Léonard M.
Durand A.
Thanomsub Wongsatayanon B.
Keywords: Cytotoxicity
Dextran
Diseases
Lanthanum compounds
Nanoparticles
Anti-proliferative activities
Cervical cancer cells
Cervical cancers
Mitochondrial pathways
Monomyristin
Polymeric nanoparticles
Targeting
Transferrin
Cytology
dextran
monoacylglycerol
monomyristin
nanoparticle
polylactide
polymer
transferrin
unclassified drug
water
antineoplastic agent
drug carrier
monoacylglycerol
nanoparticle
polymer
animal cell
antiproliferative activity
apoptosis
Article
cervical cancer cell line
controlled study
cytotoxicity
drug conjugation
drug delivery system
drug efficacy
drug solubility
female
HeLa cell line
human
human cell
in vitro study
mitochondrion
nanoencapsulation
nonhuman
priority journal
protein expression
signal transduction
Vero cell line
animal
cell culture
cell proliferation
chemistry
Chlorocebus aethiops
drug effect
drug screening
metabolism
pathology
surface property
uterine cervix tumor
Animals
Antineoplastic Agents
Apoptosis
Cell Proliferation
Cells, Cultured
Cercopithecus aethiops
Drug Carriers
Drug Screening Assays, Antitumor
Female
HeLa Cells
Humans
Monoglycerides
Nanoparticles
Polymers
Surface Properties
Uterine Cervical Neoplasms
Vero Cells
วันที่เผยแพร่: 2019
บทคัดย่อ: The cytotoxicity of monomyristin (MM), a monoacylglycerol, was investigated against cervical cancer cells (HeLa) and two normal cells (Vero and endometrial epithelial cells). MM exhibited cytotoxicity specifically to HeLa cells and not against normal cells except at the highest investigated doses (> 500 μg/mL). MM was showed to increase apoptotic dead cells by intrinsic mitochondrial pathway. To overcome the poor water solubility of MM and increase its efficacy against HeLa cells, MM was encapsulated into dextran-covered polylactide (PLA) nanoparticles (NPs). NPs comprised a PLA core which encapsulated MM and a superficial layer of dextran loops which was used for conjugating a protein, transferrin (Tf), known to be overexpressed on cancer cells’ surface. Encapsulation of MM into NPs increased its cytotoxicity against HeLa cells at lower doses of MM than free MM. Additionally, the presence of conjugated Tf further increased the cytotoxicity of MM against HeLa cells as compared to non-conjugated NPs. Remarkably, both conjugated and non-conjugated MM loaded NPs were safe to normal cells (Vero and endometrial). © 2018 Elsevier B.V.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12446
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058968630&doi=10.1016%2fj.colsurfb.2018.12.062&partnerID=40&md5=e972784520cc1a472ee4de07ed2ec9ba
ISSN: 9277765
Appears in Collections:Scopus 1983-2021

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