Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12290
ชื่อเรื่อง: Anti-xanthine oxidase activity of flavone analogues from dillenia indica L. And in silico study
ผู้แต่ง: Khammee T.
Rattanapittayapron A.
Rangjaroen C.
Jaratrungtawee A.
Kuno M.
วันที่เผยแพร่: 2019
บทคัดย่อ: Six bioactive substances have been isolated from the fruit extract of Dillenia indica L., including a triterpene lupeol (1), together with a mixture of β-sitosterol (2a) and stigmasterol (2b), three flavonols, keamferide (3), dillenetin (4), quercetin (5), and β-sitosterol-d-glucoside (6). The structures of all isolated compounds were characterized by analysis of their spectroscopic data and by comparison with the reported value of the known compounds. The investigation of anti-xanthine oxidase activity shows that compounds 3, 4, and 5 were suitable xanthine oxidase inhibitors, with IC50 value in the range of 0.56-1.44 mM. Moreover, a molecular docking study of a potent xanthine oxidase inhibitor was performed to find the binding mode of the inhibitors into the binding site of xanthine oxidase. © RASĀYAN. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12290
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076306625&doi=10.31788%2fRJC.2019.1245412&partnerID=40&md5=bf4834d23de9cd3a22b9fab1439e5b4b
ISSN: 9741496
Appears in Collections:Scopus 1983-2021

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