Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/12123
ชื่อเรื่อง: Antifungal Activity and the Chemical and Physical Stability of Microemulsions Containing Citrus hystrix DC Leaf Oil
ผู้แต่ง: Pumival P.
Tadtong S.
Athikomkulchai S.
Chittasupho C.
Keywords: antifungal agent
bicyclogermacrene
caryophyllene
caryophyllene oxide
citronellal
citronellol
citronellyl acetate
clotrimazole
delta cadinene
essential oil
geranyl acetate
hedycaryol
humulene
isopulegol
kaffir lime oil
ketoconazole
limonene
linalool
myrcene
nerol
nerolidol
neryl acetate
ocimene
polysorbate 80
propylene glycol
sabinene
terpinen 4 ol
terpinene
unclassified drug
water
antifungal activity
Article
chemical composition
Citrus
Citrus hystrix
controlled study
dispersity
drug delivery system
gas chromatography
hydrodistillation
hydrodynamics
ionization
limit of detection
limit of quantitation
mass fragmentography
mass spectrometry
microemulsion
minimum inhibitory concentration
nonhuman
photon correlation spectroscopy
plant leaf
quantitative analysis
titrimetry
ultraviolet visible spectrophotometry
zeta potential
zone of inhibition
วันที่เผยแพร่: 2020
บทคัดย่อ: Citrus hystrix DC (kaffir lime) leaf oil exhibited antifungal activities against Aspergillus niger and Candida albicans. This study aimed to evaluate the antifungal activity of kaffir lime leaf oil and microemulsions containing kaffir lime oil against Trichophyton mentagrophytes var. interdigitale. The chemical components of kaffir lime leaf oil were analyzed by gas chromatography coupled with mass spectrometry. Microemulsions containing kaffir lime oil were formulated using Tween 80, propylene glycol, and water using a phase titration method. The microemulsion of kaffir lime leaf oil was evaluated for droplet size, polydispersity index, and zeta potential using a dynamic light scattering technique. The antifungal activities of kaffir lime oil and its microemulsion were investigated through macrodilution and agar well diffusion methods, respectively. The degradation of citronellal in the microemulsion was analyzed by validated UV-Visible spectrophotometry. The minimum inhibitory concentration value of kaffir lime oil was 1.08 ± 0.00 mg/mL. The microemulsion of kaffir lime leaf oil exhibited potent antifungal activity against T. mentagrophytes var. interdigitale. The size, polydispersity index, and zeta potential of freshly prepared microemulsion were 12.82 ± 0.40 nm, 0.183 ± 0.072, and −7.87 ± 0.06 mV, respectively. The microemulsion of kaffir lime leaf oil also demonstrated good physical and chemical stability at specific temperatures. The kaffir lime oil microemulsion was highly stable when stored at 4 °C and 30 °C for 1 month but was unstable at 45 °C. The microemulsion of kaffir lime leaf oil may be an alternative therapeutic against tinea pedis caused by T. mentagrophytes var. interdigitale. © The Author(s) 2020.
URI: https://ir.swu.ac.th/jspui/handle/123456789/12123
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091078446&doi=10.1177%2f1934578X20957755&partnerID=40&md5=8129ffdc6d55528039815cf3b40501c5
ISSN: 1934578X
Appears in Collections:Scopus 1983-2021

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